Fujiwara M, Watanabe A, Hashimoto M, Yamauchi Y, Nakatsukasa H, Kobayashi M, Higashi T, Nagashima H
Biochem Med Metab Biol. 1986 Oct;36(2):207-9. doi: 10.1016/0885-4505(86)90126-x.
Infusion of an ammonium acetate solution into dogs during mannitol-induced reversible opening of the blood-brain barrier resulted in a marked rise in intracranial pressure (ICP). The preventive effect of a branched-chain amino acid (BCAA) solution on ammonia-induced brain edema was tested by measuring ICP and brain water content. The BCAA solution apparently prevented ammonia-induced brain edema, indicating that BCAA accelerated ammonia detoxification in the brain.
在甘露醇诱导犬血脑屏障可逆性开放期间，向犬输注醋酸铵溶液会导致颅内压（ICP）显著升高。通过测量颅内压和脑含水量，测试了支链氨基酸（BCAA）溶液对氨诱导的脑水肿的预防作用。BCAA溶液明显预防了氨诱导的脑水肿，表明BCAA加速了脑中氨的解毒。
