犬血脑屏障渗透性开放时高氨血症诱导的细胞毒性脑水肿
Hyperammonemia-induced cytotoxic brain edema under osmotic opening of blood-brain barrier in dogs.
作者信息
Fujiwara M, Watanabe A, Shiota T, Yamauchi Y, Nakatsukasa H, Takei N, Kobayashi K, Higashi T, Nagashima H
出版信息
Res Exp Med (Berl). 1985;185(6):425-7. doi: 10.1007/BF01851848.
PMID:3937190
Abstract
Infusion of an ammonium acetate solution into dogs during mannitol-induced reversible opening of the blood-brain barrier (BBB) resulted in a marked rise in intracranial pressure with exclusion of Evans blue dye. This indicated cytotoxic brain edema. These findings suggest a role for hyperammonemia in cerebral edema during acute liver failure.
摘要
在甘露醇诱导犬血脑屏障（BBB）可逆性开放期间，向犬输注醋酸铵溶液会导致颅内压显著升高，伊文思蓝染料无法进入。这表明存在细胞毒性脑水肿。这些发现提示高氨血症在急性肝衰竭脑水肿中起作用。
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