Somasundaram S, Sadique J
Biochem Med Metab Biol. 1986 Oct;36(2):220-30. doi: 10.1016/0885-4505(86)90129-5.
The effects of inflammation induced by the inoculation of rats with Freund's adjuvant on calcium transport by isolated rat liver mitochondria and on mitochondrial in vivo protein synthesis were investigated. Mitochondria isolated from the liver of inflamed rats exhibited (i) a reduction in 45Ca2+ uptake and, (ii) a reduction in protein synthesis. Addition of ATP to the calcium uptake medium stimulate the uptake in inflamed rat liver mitochondria. After inflammation was controlled by treatment with a mixture of Clerodendron inerme flavonoidal glycosides and indomethacin, rat liver mitochondria showed (i) an increase in 45Ca2+ uptake and, (ii) an increase in mitochondrial in vivo protein synthesis. The mechanism of mitochondrial calcium transport and the mitochondrial protein metabolism during inflammation and after treatment with anti-inflammatory drugs were discussed.
研究了用弗氏佐剂接种大鼠所诱导的炎症对离体大鼠肝线粒体钙转运及线粒体体内蛋白质合成的影响。从炎症大鼠肝脏分离出的线粒体表现出：（i）45Ca2+摄取减少；（ii）蛋白质合成减少。向钙摄取培养基中添加ATP可刺激炎症大鼠肝线粒体的摄取。在用臭茉莉黄酮苷和吲哚美辛混合物治疗控制炎症后，大鼠肝线粒体表现出：（i）45Ca2+摄取增加；（ii）线粒体体内蛋白质合成增加。讨论了炎症期间及用抗炎药物治疗后线粒体钙转运机制和线粒体蛋白质代谢。
