Bondarenko V M, Glezerov V Z, Koriagina I P
Zh Mikrobiol Epidemiol Immunobiol. 1979 May(5):94-8.
Experiments in a number of biological models showed that the cultures of E. coli isolated from the urine of children with pyelonephritis had a varied spectrum of pathogenic properties. Histologically confirmed pyelonephritis induced by intravenous infection in CBA mice, treated with 5% glucose by the method of Montgomerie et al., correlated with the bacterial adhesiveness to the epithelium and the interference with capillary permeability, registered in experiments on the pulmonary model with Evans blue used for control. The criterion for the development of pyelonephritis in mice, which was based, in the opinion of Mintogemerie et al., on the positive results, indicating the presence of the infecting agent in the culture obtained by inoculation with the samples of urine and kidney tissue, was found to be insufficient, as only 28 out of 45 cultures of E. coli isolated from the kidneys coincided with histologically confirmed cases of pyelonephritis.
在多个生物学模型中进行的实验表明，从患有肾盂肾炎的儿童尿液中分离出的大肠杆菌培养物具有多种致病特性。通过蒙哥马利等人的方法用5%葡萄糖治疗的经组织学证实由静脉感染诱导的CBA小鼠肾盂肾炎，与细菌对上皮的粘附性以及对毛细血管通透性的干扰相关，这在使用伊文思蓝作为对照的肺部模型实验中得到记录。蒙托杰梅里等人认为，小鼠肾盂肾炎发展的标准基于阳性结果，即接种尿液和肾脏组织样本后获得的培养物中存在感染因子，但发现该标准并不充分，因为从肾脏分离出的45株大肠杆菌培养物中只有28株与组织学证实的肾盂肾炎病例相符。
