Guze L B, Silverblatt F, Montgomerie J Z, Ishida K, Kalmanson G M
Scand J Infect Dis. 1983;15(1):57-64. doi: 10.3109/inf.1983.15.issue-1.09.
The role of pili as a bacterial virulence factor has been studied. The model used was acute ascending Escherichia coli pyelonephritis in the mouse. Three strains of E. coli were injected in lightly or more heavily piliated phases into 15 mice each. At sacrifice of 13-15 animals 2 weeks later, no significant difference in severity of pyelonephritis was found as judged by numbers of bacteria in the kidney, nor intensity or frequency of gross abscesses. 27 strains of E. coli were order ranked for severity of pyelonephritis produced and compared with intensity of piliation in vitro under conditions designed to maximize pilus formation. No significant difference was found. 15 strains derived from patients in whom infections were confined to the bladder were compared for degree of piliation with 12 strains infecting the kidney. No significant difference was found. These studies do not support a significant role for the degree of piliation as a virulence factor in pyelonephritis.
菌毛作为一种细菌毒力因子的作用已得到研究。所采用的模型是小鼠急性上行性大肠杆菌肾盂肾炎。将三株大肠杆菌在菌毛形成程度较轻或较重的阶段分别注射到15只小鼠体内。两周后处死13 - 15只动物，根据肾脏中的细菌数量、肉眼可见脓肿的严重程度或频率判断，肾盂肾炎的严重程度没有显著差异。根据所产生的肾盂肾炎的严重程度对27株大肠杆菌进行排序，并在旨在最大化菌毛形成的条件下与体外菌毛形成强度进行比较。未发现显著差异。将15株来自仅感染膀胱的患者的菌株与12株感染肾脏的菌株的菌毛形成程度进行比较。未发现显著差异。这些研究不支持菌毛形成程度在肾盂肾炎中作为毒力因子发挥重要作用。
