Development. 2023 Oct 1;150(19). doi: 10.1242/dev.202337. Epub 2023 Oct 3.
The growth factor Fgf8a has been suggested to act as a morphogen during zebrafish gastrulation, spreading from a localized source to form a concentration gradient and impart positional information to cells along a tissue field. In a new paper in Development, Michael Brand and colleagues directly visualize the endogenous Fgf8a gradient in the developing zebrafish embryo. We caught up with the first author Rohit Krishnan Harish, and his PhD supervisor Michael Brand, Professor at the Center for Regenerative Therapies (CRTD) at TU Dresden.
生长因子 Fgf8a 在斑马鱼原肠胚形成过程中被认为是一种形态发生素,它从一个局部来源扩散,形成浓度梯度,并向组织场中的细胞传递位置信息。在《发育》杂志上的一篇新论文中,Michael Brand 及其同事直接观察到了发育中的斑马鱼胚胎中内源性 Fgf8a 梯度。我们采访了第一作者 Rohit Krishnan Harish 和他的博士导师 Michael Brand,后者是德累斯顿工业大学再生治疗中心(CRTD)的教授。