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苯佐卡因和利多卡因生物黏附贴片在儿童各种小型口腔外科手术中的疗效——一项评估研究。

Efficacy of benzocaine and lidocaine bioadhesive patches in various minor oral surgical procedures in children - An evaluative study.

作者信息

John Nisha E, Erakkodan Ramakrishnan, Sreelakshmi Natta

机构信息

Department of Pedodontics and Preventive Dentistry, KMCT Dental College, Calicut, Kerala, India.

出版信息

Indian J Dent Res. 2023 Apr-Jun;34(2):145-149. doi: 10.4103/ijdr.ijdr_192_21.

Abstract

CONTEXT

The key to successful management of a child in the dental clinic depends greatly on providing painless anaesthesia. Topical anaesthesia using bioadhesive patches may be a breakthrough in this field.

AIMS

The purpose of the study was to compare the efficacy of Benzocaine and Lidocaine bioadhesive patches in reducing pain associated with various minor oral surgical procedures in children.

METHODS AND MATERIALS

Hundred subjects, aged 6-9 years, requiring various minor oral surgical procedures such as extractions of primary teeth, nerve blocks, mucocele excision or drainage of abscesses were divided equally into Groups 1 and 2. In Group 1, custom fabricated Benzocaine patches were placed for 5 minutes at the target site prior to the procedure, and in Group 2, Lidocaine patches were used in the same manner. Each subject completed a visual analogue scale (VAS) and Wong-Baker Faces pain scale (FPS) after each procedure. Pulse rate and saturation of peripheral oxygen were assessed using pulse oximeter. The duration of the study was from September 2014 to September 2015.

STATISTICAL ANALYSIS USED

The statistical analysis was done using paired t test, ANOVA and Bonferroni post hoc analysis. P value less than 0.05 were considered as statistically significant.

RESULTS

A significant difference in pain scores was observed favouring the use of Benzocaine over Lidocaine patches (P < 0.05). However, no significant differences in pulse oximeter readings were observed.

CONCLUSIONS

A statistically significant reduction in pain rating scores was observed in the Benzocaine group after a five-minute application of the patch.

摘要

背景

在牙科诊所成功管理儿童患者的关键很大程度上取决于提供无痛麻醉。使用生物粘附贴片的局部麻醉可能是该领域的一项突破。

目的

本研究的目的是比较苯佐卡因和利多卡因生物粘附贴片在减轻儿童各种小型口腔外科手术相关疼痛方面的疗效。

方法和材料

100名年龄在6至9岁之间、需要进行各种小型口腔外科手术(如乳牙拔除、神经阻滞、黏液囊肿切除或脓肿引流)的受试者被平均分为第1组和第2组。在第1组中,在手术前将定制的苯佐卡因贴片在目标部位放置5分钟,在第2组中,以相同方式使用利多卡因贴片。每个受试者在每次手术后完成视觉模拟量表(VAS)和面部表情疼痛量表(FPS)。使用脉搏血氧仪评估脉搏率和外周血氧饱和度。研究持续时间为2014年9月至2015年9月。

所用统计分析方法

采用配对t检验、方差分析和Bonferroni事后分析进行统计分析。P值小于0.05被认为具有统计学意义。

结果

观察到疼痛评分存在显著差异,支持使用苯佐卡因贴片而非利多卡因贴片(P < 0.05)。然而,脉搏血氧仪读数未观察到显著差异。

结论

在苯佐卡因组中,贴片应用5分钟后观察到疼痛评分在统计学上显著降低。

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