循环 S100A8/A9 水平升高而非尿液 S100A8/A9 水平升高可识别 COVID-19 不良结局。
Elevated Level of Circulating but Not Urine S100A8/A9 Identifies Poor COVID-19 Outcomes.
机构信息
Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri 63108, United States.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63108, United States.
出版信息
ACS Infect Dis. 2023 Oct 13;9(10):1815-1820. doi: 10.1021/acsinfecdis.3c00249. Epub 2023 Oct 3.
The alarmin calprotectin (S100A8/A9) is thought to drive a cytokine storm, a hallmark of severe COVID-19. Recent studies report circulating S100A8/A9 levels can distinguish COVID-19 severity but have only been conducted in non-U.S. cohorts and mainly focus on serum S100A8/A9 levels. Thus, we quantified S100A8/A9 in serum and urine samples from a hospital cohort in St. Louis, Missouri, to expand the understanding of S100A8/A9 as a prognostic biomarker for COVID-19. Elevated S100A8/A9 serum levels were observed in ICU patients ( = 49, = 0.0370) and patients with fatal cases of COVID-19 ( = 76, = 0.0018). We observed no correlation in the S100A8/A9 levels in matched serum and urine samples. Our results support the association of serum S100A8/A9 levels with COVID-19 severity and suggest that further investigation of urine S100A8/A9 as a COVID-19 biomarker is not warranted.
警报素钙卫蛋白（S100A8/A9）被认为可引发细胞因子风暴，这是严重 COVID-19 的一个标志。最近的研究报告称，循环 S100A8/A9 水平可区分 COVID-19 的严重程度，但这些研究仅在非美国队列中进行，且主要集中在血清 S100A8/A9 水平上。因此，我们对密苏里州圣路易斯一家医院队列的血清和尿液样本中的 S100A8/A9 进行了定量分析，以扩大对 S100A8/A9 作为 COVID-19 预后生物标志物的认识。我们观察到 ICU 患者（ = 49， = 0.0370）和 COVID-19 死亡病例患者（ = 76， = 0.0018）的血清 S100A8/A9 水平升高。我们在匹配的血清和尿液样本中没有观察到 S100A8/A9 水平的相关性。我们的研究结果支持血清 S100A8/A9 水平与 COVID-19 严重程度的关联，并表明进一步研究尿液 S100A8/A9 作为 COVID-19 生物标志物是没有必要的。
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