Pekala R W, Rudoltz M, Lang E R, Merrill E W, Lindon J, Kushner L, McManama G, Salzman E W
Biomaterials. 1986 Sep;7(5):372-8. doi: 10.1016/0142-9612(86)90008-6.
The interaction of blood with new artificial surfaces is an area of continual medical interest. In this study, a series of polyether/polysiloxane networks were synthesized, characterized in terms of both bulk and surface compositions, and evaluated for blood compatibility. The crosslinked networks were produced by reacting the epoxy groups of polyglycidoxy propyl methyl siloxane (PGPMS) with the hydroxyl end groups of polypropylene glycol (PPG). Blood compatibility was evaluated using an in vitro platelet retention test and fibrinogen adsorption experiments from human plasma and buffered saline. The PPG/PGPMS networks exhibit low fibrinogen adsorption and low platelet activation. Such properties make the networks potentially attractive as materials for blood-interfacing applications.
血液与新型人工表面的相互作用是医学领域持续关注的一个方面。在本研究中，合成了一系列聚醚/聚硅氧烷网络，对其本体和表面组成进行了表征，并评估了其血液相容性。交联网络是通过聚缩水甘油氧基丙基甲基硅氧烷（PGPMS）的环氧基团与聚丙二醇（PPG）的羟基端基反应制备的。使用体外血小板滞留试验以及来自人血浆和缓冲盐水的纤维蛋白原吸附实验评估血液相容性。PPG/PGPMS网络表现出低纤维蛋白原吸附和低血小板活化。这些特性使该网络作为血液接触应用材料具有潜在吸引力。
