Kim Gi Eun, Ansari Soubiya Mohammed Rizwan, Ali Ateeque Mohamed, Adam Ehab, Eltahir Mugahid
Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
Weill Cornell Medicine-Qatar, Doha, Qatar.
Eur J Case Rep Intern Med. 2023 Aug 31;10(10):004041. doi: 10.12890/2023_004041. eCollection 2023.
Linezolid is known to cause side effects, including nausea, diarrhea, and headaches of short duration. As extended use of linezolid is becoming more common, additional rare side effects should be considered.
A 68-year-old man hospitalized for osteomyelitis developed severe abdominal pain and altered mental status following five weeks of linezolid therapy. Laboratory studies showed very high lipase levels, lactic acidosis not responding to resuscitation, and relative hypoglycemia. All common causes of pancreatitis were ruled out, and a trial of linezolid withdrawal was done resulting in drastic improvement in the patient's clinical status.
For patients on extended course of linezolid who develop abdominal pain, drug-induced pancreatitis should be considered as a side effect, and a trial of withdrawal of linezolid should be undertaken.
Linezolid can be associated with a rare but serious triad of adverse effects of pancreatitis, hypoglycemia, and lactic acidosis.Possible risk factors include a prolonged course of linezolid, renal dysfunction, and sepsis.
已知利奈唑胺会引起副作用，包括恶心、腹泻和短期头痛。随着利奈唑胺的长期使用越来越普遍，应考虑其他罕见的副作用。
一名因骨髓炎住院的68岁男性在接受利奈唑胺治疗五周后出现严重腹痛和精神状态改变。实验室检查显示脂肪酶水平非常高、乳酸酸中毒对复苏无反应以及相对性低血糖。排除了胰腺炎的所有常见病因，并进行了停用利奈唑胺的试验，结果患者的临床状况大幅改善。
对于接受长期利奈唑胺治疗且出现腹痛的患者，应考虑药物性胰腺炎作为一种副作用，并应进行停用利奈唑胺的试验。
利奈唑胺可能与胰腺炎、低血糖和乳酸酸中毒这一罕见但严重的不良反应三联征有关。可能的风险因素包括利奈唑胺疗程延长、肾功能不全和脓毒症。
