利奈唑胺毒性三联征：低血糖、乳酸酸中毒和急性胰腺炎。
A triad of linezolid toxicity: hypoglycemia, lactic acidosis, and acute pancreatitis.
作者信息
Johnson P Connor, Vaduganathan Muthiah, Phillips Kristy M, O'Donnell Walter J
机构信息
Department of Medicine (Johnson, Vaduganathan), Department of Pharmacy (Phillips), and Department of Pulmonary and Critical Care Medicine (O'Donnell), Massachusetts General Hospital, Boston, Massachusetts.
出版信息
Proc (Bayl Univ Med Cent). 2015 Oct;28(4):466-8. doi: 10.1080/08998280.2015.11929310.
Abstract
We present a case of suspected linezolid toxicity in a 34-year-old man with sickle cell disease and line-related vancomycin-resistant enterococcal bacteremia and tricuspid valve endocarditis. The patient developed sudden-onset hypoglycemia, lactic acidosis, and acute pancreatitis 11 days after initiation of linezolid. All adverse effects quickly resolved with drug cessation. The pathophysiology underlying this triad of linezolid toxicity is unclear, but may be related to mitochondrial dysfunction.
摘要
我们报告了一例34岁患有镰状细胞病且伴有与血管内导管相关的耐万古霉素肠球菌菌血症及三尖瓣心内膜炎的男性患者，怀疑发生了利奈唑胺毒性反应。该患者在开始使用利奈唑胺11天后出现了突发低血糖、乳酸性酸中毒和急性胰腺炎。停用药物后，所有不良反应迅速消失。利奈唑胺毒性反应这一三联征的潜在病理生理学机制尚不清楚，但可能与线粒体功能障碍有关。
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