Alalola Bassam, Asiri Ali, Binmoghaiseeb Ibraheem, Baharoon Waleed, Alrassi Yazeed, Alanizy Bandar, Alsayari Hesham
Preventive Dental Science, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, SAU.
Research and Development, King Abdullah International Medical Research Center, Riyadh, SAU.
Cureus. 2023 Sep 1;15(9):e44535. doi: 10.7759/cureus.44535. eCollection 2023 Sep.
Orthodontists may encounter patients with alveolar bony defects, which are often treated with various bone-grafting materials. The effects of different bone-grafting materials on orthodontic tooth movement (OTM) are of concern to orthodontists. Therefore, we aimed to evaluate the current status of the literature that reports on the effects of different bone-grafting materials on OTM in terms of the rate and side effects. An electronic search of the PubMed and Scopus databases and Google Scholar was performed. Two reviewers independently conducted the screening process using COVIDENCE™, and a third reviewer resolved any conflicts. SYRCLE's (Systematic Review Centre for Laboratory Animal Experimentation's) risk-of-bias tool for animal studies was utilized to assess the quality of the included studies. Out of 457 initial titles, 11 studies were finally included for data extraction. All of the included studies were animal experiments, and none of them were considered to have a low risk of bias. The included studies had varied results. However, a general tendency existed, whereby OTM in surgically treated areas with no bone grafting presented the highest OTM rate. In cases where a bone graft was used, xenografts revealed the highest OTM rate, followed by alloplasts. Lastly, the use of allografts resulted in the slowest OTM rates. The most common side effect was root resorption. In conclusion, there is a lack of high-quality evidence regarding the effects of bone-grafting materials on OTM rate. Due to the lack of human subjects, RCTs, and the heterogeneity of subjects in the current literature, the impact of bone-grafting materials on OTM deserves further investigations using more rigorous scientific methodologies.
正畸医生可能会遇到患有牙槽骨缺损的患者，这类患者通常采用各种骨移植材料进行治疗。不同骨移植材料对正畸牙齿移动（OTM）的影响是正畸医生所关注的。因此，我们旨在从速率和副作用方面评估报告不同骨移植材料对OTM影响的文献现状。我们对PubMed和Scopus数据库以及谷歌学术进行了电子检索。两名评审员使用COVIDENCE™独立进行筛选过程，第三名评审员解决任何冲突。利用SYRCLE（实验动物实验系统评价中心）的动物研究偏倚风险工具来评估纳入研究的质量。在457个初始标题中，最终纳入11项研究进行数据提取。所有纳入研究均为动物实验，且无一被认为具有低偏倚风险。纳入研究的结果各不相同。然而，存在一种普遍趋势，即未进行骨移植的手术治疗区域的OTM速率最高。在使用骨移植的情况下，异种移植物的OTM速率最高，其次是同种异体人工骨。最后，同种异体移植物导致的OTM速率最慢。最常见的副作用是牙根吸收。总之，关于骨移植材料对OTM速率影响的高质量证据不足。由于目前文献中缺乏人类受试者、随机对照试验以及受试者的异质性，骨移植材料对OTM的影响值得使用更严格的科学方法进行进一步研究。
