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一名遗传性血色素沉着症患者的耐药性帕金森病:病例报告

Drug-Resistant Parkinson's Disease in a Patient With Hereditary Hemochromatosis: A Case Report.

作者信息

Banta Conor W, Zonna Xavier, Lott Ronald, Jaisawal Pooja, Elsisi Amr

机构信息

Internal Medicine, Geisinger Commonwealth School of Medicine, Scranton, USA.

Internal Medicine, Lake Erie College of Osteopathic Medicine, Erie, USA.

出版信息

Cureus. 2023 Sep 1;15(9):e44530. doi: 10.7759/cureus.44530. eCollection 2023 Sep.

Abstract

A 55-year-old male, with a strong family history of hereditary hemochromatosis, presented with progressively worsening right-sided tremor and Parkinsonian symptoms. He was diagnosed with hereditary hemochromatosis based on genetic testing and started undergoing regular phlebotomies to reduce his blood iron levels. Despite extensive trials of different pharmaceutical therapies, including levodopa-carbidopa, his Parkinsonian symptoms were not relieved and continued to worsen. This report serves to highlight the importance of early disease identification and intervention in patients with hereditary hemochromatosis to prevent the development of neurological sequelae, as well as a need for further research into effective therapies in such patients.

摘要

一名55岁男性,有遗传性血色素沉着症的家族病史,出现右侧震颤和帕金森症状逐渐加重。基于基因检测,他被诊断为遗传性血色素沉着症,并开始定期进行放血以降低其血铁水平。尽管对包括左旋多巴-卡比多巴在内的不同药物疗法进行了广泛试验,但他的帕金森症状并未缓解且持续恶化。本报告旨在强调对遗传性血色素沉着症患者进行早期疾病识别和干预以预防神经后遗症发生的重要性,以及对此类患者有效疗法进行进一步研究的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f5/10544707/787ee7ab996c/cureus-0015-00000044530-i01.jpg

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