Feng Shiyan, Wang Fengxin, Wu Weibo, Li Yinfeng, Chen Chuming, Li Jianming, Cao Mengli, Peng Ling, Zhang Peiyan, Wang Fuxiang
Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.
J Med Biochem. 2023 Aug 25;42(3):444-453. doi: 10.5937/jomb0-41502.
This study aims to analyze the changes and significance of organ function indices in patients with severe Coronavirus Disease 2019 (COVID-19) pneumonia for prediction of major organ damages and guiding treatment schemes.
63 patients with severe COVID-19 pneumonia were selected as the severe group and 73 patients with mild syndromes were selected as the mild group. SAS9.4 software was used for statistical analysis of the data.
Levels of ALT, AST, cTnI, Cr, PT, APTT and Ddimer of the severe group were significantly higher while PLT was lower than those of the mild group. The data of all quantitative variables were converted into categorical variables. Significantly higher levels of AST, ALB, D-dimer and higher proportion of bilateral lung involvement were observed from the severe group comparing to those in the mild group, while the difference in the other indices between the two groups was insignificant in statistical perspective.
There are significant differences in the levels of multiple organ function indices between the severe group and the mild group of patients with COVID-19 pneumonia infection. Through examining the relevant indices, conditions of patients' multiple organ function damage could be predicted and used as guidance of treatment.
本研究旨在分析新型冠状病毒肺炎（COVID-19）重症患者器官功能指标的变化及其意义，以预测主要器官损伤并指导治疗方案。
选取63例COVID-19重症肺炎患者作为重症组，73例轻症患者作为轻症组。采用SAS9.4软件对数据进行统计分析。
重症组谷丙转氨酶（ALT）、谷草转氨酶（AST）、肌钙蛋白I（cTnI）、肌酐（Cr）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）及D-二聚体水平显著高于轻症组，而血小板（PLT）水平低于轻症组。将所有定量变量数据转换为分类变量。与轻症组相比，重症组AST、白蛋白（ALB）、D-二聚体水平显著升高，双侧肺受累比例更高，而两组间其他指标差异无统计学意义。
COVID-19肺炎感染重症组与轻症组患者多项器官功能指标水平存在显著差异。通过检测相关指标，可预测患者多器官功能损伤情况并指导治疗。
