Wilkinson Carol L, Yankowitz Lisa, Chao Jerry Y, Gutiérrez Rodrigo, Rhoades Jeff L, Shinnar Shlomo, Purdon Patrick L, Nelson Charles A
Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, United States.
Harvard Medical School, Boston, MA, USA.
Res Sq. 2023 Sep 18:rs.3.rs-3215728. doi: 10.21203/rs.3.rs-3215728/v1.
The development of neural circuits over the first years of life has long-lasting effects on brain function, yet our understanding of early circuit development in humans remains limited. Here, aperiodic and periodic EEG power features were examined from longitudinal EEGs collected from 592 healthy 2-44 month-old infants, revealing age-dependent nonlinear changes suggestive of distinct milestones in early brain maturation. Consistent with the transient developmental progression of thalamocortical circuitry, we observe the presence and then absence of periodic alpha and high beta peaks across the three-year period, as well as the emergence of a low beta peak (12-20Hz) after six months of age. We present preliminary evidence that the emergence of the low beta peak is associated with thalamocortical connectivity sufficient for anesthesia-induced alpha coherence. Together, these findings suggest that early age-dependent changes in alpha and beta periodic peaks may reflect the state of thalamocortical network development.
生命最初几年神经回路的发育对脑功能具有长期影响，但我们对人类早期神经回路发育的了解仍然有限。在此，我们对592名2至44个月大健康婴儿的纵向脑电图进行了分析，检测了非周期性和周期性脑电图功率特征，发现了与年龄相关的非线性变化，这表明早期大脑成熟过程中存在不同的里程碑。与丘脑皮质回路的短暂发育进程一致，我们观察到在三年期间周期性α波和高β波峰值先出现后消失，以及在6个月大后出现了低β波峰值（12 - 20Hz）。我们提供了初步证据，表明低β波峰值的出现与足以产生麻醉诱导α波相干性的丘脑皮质连接性有关。这些发现共同表明，α波和β波周期性峰值的早期年龄依赖性变化可能反映了丘脑皮质网络的发育状态。
