Wilkinson Carol L, Yankowitz Lisa, Chao Jerry Y, Gutiérrez Rodrigo, Rhoades Jeff L, Shinnar Shlomo, Purdon Patrick L, Nelson Charles A
Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, United States.
Harvard Medical School, Boston, MA, USA.
bioRxiv. 2024 Mar 9:2023.07.21.550114. doi: 10.1101/2023.07.21.550114.
The development of neural circuits has long-lasting effects on brain function, yet our understanding of early circuit development in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected from 592 healthy 2-44 month-old infants, revealing age-dependent nonlinear changes suggestive of distinct milestones in early brain maturation. Consistent with the transient developmental progression of thalamocortical circuitry, we observe the presence and then absence of periodic alpha and high beta peaks across the three-year period, as well as the emergence of a low beta peak (12-20Hz) after six months of age. We present preliminary evidence that the emergence of the low beta peak is associated with higher thalamocortical-dependent, anesthesia-induced alpha coherence. Together, these findings suggest that early age-dependent changes in alpha and beta periodic peaks may reflect the state of thalamocortical network development.
神经回路的发育对脑功能具有长期影响，但我们对人类早期回路发育的了解仍然有限。在此，我们从592名2至44个月大的健康婴儿收集的纵向脑电图中检查了周期性脑电图功率特征和非周期性成分，揭示了与年龄相关的非线性变化，提示早期脑成熟过程中存在不同的里程碑。与丘脑皮质回路的短暂发育进程一致，我们观察到在三年期间周期性阿尔法和高贝塔峰值先出现后消失，以及在六个月大后出现低贝塔峰值（12 - 20Hz）。我们提供了初步证据表明低贝塔峰值的出现与更高的丘脑皮质依赖性、麻醉诱导的阿尔法相干性有关。这些发现共同表明，阿尔法和贝塔周期性峰值的早期年龄依赖性变化可能反映了丘脑皮质网络的发育状态。
