Wang Pei, Wang Xiao-Yan, Man Chang-Feng, Gong Dan-Dan, Fan Yu
Cancer Institute, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Department of Gastroenterology, The Affiliated Suqian First People's Hospital of Xuzhou Medical University, Suqian, Jiangsu, China.
Front Oncol. 2023 Sep 15;13:1200619. doi: 10.3389/fonc.2023.1200619. eCollection 2023.
Hyperbaric oxygen therapy is a relatively safe treatment method that has been used for a long time in the clinic. It has been proven that it can enhance the sensitivity of radiotherapy and photodynamic therapy for cancer. However, there are few studies on hyperbaric oxygen and immunotherapy. In this article, we summarize that hyperbaric oxygen therapy regulates the tumor microenvironment through various pathways such as improving tumor hypoxia, targeting hypoxia-inducing factors, and generating reactive oxygen species. The change in the tumor microenvironment ultimately affects the curative effect of immunotherapy. Therefore, hyperbaric oxygen can influence immunotherapy by regulating the tumor microenvironment, providing a direction for the future development of immunotherapy.
高压氧疗法是一种相对安全的治疗方法，在临床上已应用多年。业已证明，它可增强放疗和光动力疗法对癌症的敏感性。然而，关于高压氧与免疫疗法的研究较少。在本文中，我们总结了高压氧疗法通过改善肿瘤缺氧、靶向缺氧诱导因子和产生活性氧等多种途径调节肿瘤微环境。肿瘤微环境的变化最终影响免疫疗法的疗效。因此，高压氧可通过调节肿瘤微环境影响免疫疗法，为免疫疗法的未来发展提供了方向。
