Ilfeld D, Barzilay J, Dux Z, Ran M
Breast Cancer Res Treat. 1986;7(3):181-6. doi: 10.1007/BF01806248.
Patients with carcinomas have elevated levels of Fc receptors for IgG (Fc gamma R) on their peripheral blood mononuclear cells (PBMC). The purpose of the present study was to determine whether there is a correlation between Fc gamma R levels on PBMC and survival in patients with metastatic breast cancer. Binding assays were performed on PBMC using 125I-labeled fibrinogen complexed with rabbit IgG (or as a control F(ab')2) anti-human fibrinogen. Twenty-two metastatic breast cancer patients had significantly (p less than 0.001) elevated Fc gamma R levels as compared to either 22 breast cancer patients receiving adjuvant chemotherapy following mastectomy without clinical evidence of tumor, or to 34 non-malignant controls. Significantly more metastatic patients with elevated Fc gamma R levels died at 6 months (p less than 0.001) as compared to those with low levels. A direct correlation between Fc gamma R levels and hazard probability was found (correlation coefficient = 0.3321, p less than 0.005). These results raise the possibility that Fc gamma R levels on PBMC from metastatic breast cancer patients may be clinically useful as a prognostic marker of disease activity.
癌症患者外周血单个核细胞（PBMC）上的IgG Fc受体（FcγR）水平升高。本研究的目的是确定PBMC上的FcγR水平与转移性乳腺癌患者的生存率之间是否存在相关性。使用与兔IgG（或作为对照的F(ab')2）抗人纤维蛋白原复合的125I标记纤维蛋白原对PBMC进行结合测定。与22例接受乳房切除术后辅助化疗且无肿瘤临床证据的乳腺癌患者或34例非恶性对照相比，22例转移性乳腺癌患者的FcγR水平显著升高（p<0.001）。与FcγR水平低的转移性患者相比，FcγR水平高的转移性患者在6个月时死亡的人数显著更多（p<0.001）。发现FcγR水平与风险概率之间存在直接相关性（相关系数=0.3321，p<0.005）。这些结果增加了一种可能性，即转移性乳腺癌患者PBMC上的FcγR水平可能作为疾病活动的预后标志物具有临床应用价值。
