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Going Further With Half as Much: It's in the BAG.

作者信息

Kirk Jonathan A

机构信息

Department of Cell and Molecular Physiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA.

出版信息

JACC Basic Transl Sci. 2023 Sep 25;8(9):1212-1214. doi: 10.1016/j.jacbts.2023.06.008. eCollection 2023 Sep.

DOI:10.1016/j.jacbts.2023.06.008
PMID:37791297
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10544100/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3212/10544100/eedbec11128b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3212/10544100/5cbd97cb62e7/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3212/10544100/eedbec11128b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3212/10544100/5cbd97cb62e7/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3212/10544100/eedbec11128b/gr1.jpg

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本文引用的文献

1
An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3.一项无偏筛选确定热休克蛋白70- BAG3复合物是肌球蛋白结合蛋白C3的调节剂。
JACC Basic Transl Sci. 2023 Aug 2;8(9):1198-1211. doi: 10.1016/j.jacbts.2023.04.009. eCollection 2023 Sep.
2
Therapeutic targeting of BAG3: considering its complexity in cancer and heart disease.靶向 BAG3 的治疗策略：考虑其在癌症和心脏病中的复杂性。
J Clin Invest. 2021 Aug 16;131(16). doi: 10.1172/JCI149415.
3
Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover.
心力衰竭中心肌细胞收缩功能障碍是由于 BAG3 介导线粒体蛋白周转减少所致。
Nat Commun. 2021 May 19;12(1):2942. doi: 10.1038/s41467-021-23272-z.
4
HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C.HSC70 是野生型和突变型心肌肌球蛋白结合蛋白 C 的伴侣。
JCI Insight. 2018 Jun 7;3(11). doi: 10.1172/jci.insight.99319.
5
Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy.共伴侣蛋白BAG3的功能丧失突变会使小分子热休克蛋白不稳定并导致心肌病。
J Clin Invest. 2017 Aug 1;127(8):3189-3200. doi: 10.1172/JCI94310. Epub 2017 Jul 24.
6
Myosin heavy chain is stabilized by BCL-2 interacting cell death suppressor (BIS) in skeletal muscle.肌球蛋白重链在骨骼肌中由BCL-2相互作用细胞死亡抑制因子（BIS）稳定。
Exp Mol Med. 2016 Apr 1;48(4):e225. doi: 10.1038/emm.2016.2.
7
Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer.热休克蛋白70（Hsp70）与Bag3蛋白相互作用作为癌症潜在治疗靶点的验证
Mol Cancer Ther. 2015 Mar;14(3):642-8. doi: 10.1158/1535-7163.MCT-14-0650. Epub 2015 Jan 6.