Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Nat Prod Rep. 2024 Jan 24;41(1):25-58. doi: 10.1039/d3np00022b.
Covering: 1925 to July 2023Among the sesquiterpenoids with rich structural diversity and potential bioactivities, lindenane sesquiterpenoids (LSs) possess a characteristic , -3,5,6-carbocyclic skeleton and mainly exist as monomers and diverse oligomers in plants from the genus and Chloranthaceae family. Since the first identification of lindeneol from in 1925, 354 natural LSs and their oligomers with anti-inflammatory, antitumor, and anti-infective activities have been discovered. Structurally, two-thirds of LSs exist as oligomers with interesting skeletons through diverse polymeric patterns, especially Diels-Alder [4 + 2] cycloaddition. Fascinated by their diverse bioactivities and intriguing polycyclic architectures, synthetic chemists have engaged in the total synthesis of natural LSs in recent decades. In this review, the research achievements related to LSs from 1925 to July of 2023 are systematically and comprehensively summarized, focusing on the classification of their structures, chemical synthesis, and bioactivities, which will be helpful for further research on LSs and their oligomers.
1925 年至 2023 年 7 月
在具有丰富结构多样性和潜在生物活性的倍半萜类化合物中，[lindenane sesquiterpenoids（LSs）]具有特征性的，-3,5,6-碳环骨架，主要以单体和各种低聚物的形式存在于[木兰属]和金粟兰科植物中。自 1925 年首次从[linden]中鉴定出[lindeneol]以来，已经发现了 354 种具有抗炎、抗肿瘤和抗感染活性的天然 LSs 及其低聚物。在结构上，三分之二的 LSs 以有趣的骨架存在于通过不同聚合模式形成的低聚物中，特别是[Diels-Alder [4 + 2] cycloaddition]。由于其多样的生物活性和引人入胜的多环结构，合成化学家在过去几十年中一直致力于天然 LSs 的全合成。在这篇综述中，系统全面地总结了 1925 年至 2023 年 7 月期间有关 LSs 的研究成果，重点介绍了它们的结构分类、化学合成和生物活性，这将有助于进一步研究 LSs 及其低聚物。
