State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
Nat Prod Rep. 2024 Sep 18;41(9):1368-1402. doi: 10.1039/d4np00005f.
Covering: 1976 to December 2023Chloranthaceae is comprised of four extant genera (, , , and ), totaling about 80 species, many of which have been widely used as herbal medicines for diverse medical purposes. Chloranthaceae plants represent a rich source of structurally interesting and diverse secondary metabolites, with sesquiterpenoids and diterpenoids being the predominant structural types. Lindenane sesquiterpenoids and their oligomers, chemotaxonomical markers of the family Chloranthaceae, have shown a wide spectrum of bioactivities, attracting significant attention from organic chemists and pharmacologists. Recent achievements also demonstrated the research value of two unique structural types in this plant family, sesquiterpenoid-monoterpenoid heterodimers and meroterpenoids. This review systematically summarizes 682 structurally characterized terpenoids from 22 Chloranthaceae plants and their key biological activities as well as the chemical synthesis of selected terpenoids.
1976 年至 2023 年 12 月 金粟兰科由四个现存属（金粟兰属、银线草属、鱼子兰属和草珊瑚属）组成，共有约 80 种，其中许多种被广泛用作草药，具有多种医疗用途。金粟兰科植物是结构有趣和多样化的次生代谢产物的丰富来源，其中倍半萜和二萜是主要的结构类型。里兰烷倍半萜及其低聚物是金粟兰科的化学分类学标记物，具有广泛的生物活性，引起了有机化学家与药理学家的高度关注。最近的研究成果也证明了该植物科中两个独特结构类型的研究价值，即倍半萜-单萜杂二聚体和混合萜。本文系统地总结了 22 种金粟兰科植物中 682 种结构特征明确的萜类化合物及其关键生物活性，以及部分萜类化合物的化学合成。
