Sandström P E
Br J Pharmacol. 1986 Oct;89(2):307-12. doi: 10.1111/j.1476-5381.1986.tb10261.x.
The effect of probenecid on frusemide-induced diuresis and hyperglycaemia was studied in mice. Probenecid, a known inhibitor of tubular secretion of organic anions in the kidney, strongly reduced the diuretic response to frusemide (25 or 200 mg kg-1 body weight). This effect of probenecid appeared to be dose-dependent up to 240 mg kg-1 body weight, at least at the lower concentration of frusemide. Pretreatment with probenecid (240 mg kg-1 body weight) potentiated the hyperglycaemic effect of frusemide (25 or 200 mg kg-1 body weight). The results show that probenecid has opposite effects on frusemide-induced diuresis and hyperglycaemia in mice. It is suggested that the acute hyperglycaemic effect of frusemide is not directly linked to diuresis.
在小鼠中研究了丙磺舒对速尿诱导的利尿和高血糖的影响。丙磺舒是一种已知的肾脏中有机阴离子肾小管分泌抑制剂，它能显著降低对速尿（25或200毫克/千克体重）的利尿反应。丙磺舒的这种作用在体重达240毫克/千克体重时似乎呈剂量依赖性，至少在速尿较低浓度时如此。用丙磺舒（240毫克/千克体重）预处理可增强速尿（25或200毫克/千克体重）的高血糖作用。结果表明，丙磺舒对小鼠速尿诱导的利尿和高血糖有相反的作用。提示速尿的急性高血糖作用与利尿无直接关联。
