Valmin K, Hansen T, Rønsted P
Pharmatherapeutica. 1980;2(5):296-304.
A double-blind, randomized, crossover trial was carried out in 26 hypertensive patients to investigate the hypotensive effects of three different dosages of frusemide (40 mg, 60 mg, and 80 mg twice daily) and the effects on serum potassium and urinary output. The study included a 4-week treatment period with placebo, three periods of 6 weeks with frusemide, and an intervening placebo period of 4 weeks. The mean arterial blood pressure fell about 10 mmHg within the first 2 weeks and was independent of the frusemide dosage. During the following weeks of treatment, there was a constant, slow fall in blood pressure. The period on placebo was too brief for values to return to the initial level. In contrast, the increase in urinary output, which was dose-dependent, ceased when medication was withdrawn. The diuretic effect was maintained throughout the treatment periods. There was a correlation between the fall in serum potassium and the diuretic effect whereas no correlation with the fall in blood pressure could be shown. Except for a significant increase in serum zinc, no changes were observed in other electrolyte parameters. Body weight, pulse, haemoglobin and erythrocyte sedimentation rate remained unchanged. Side-effects were few and mild, but tended to increase with higher doses.
对26名高血压患者进行了一项双盲、随机、交叉试验，以研究三种不同剂量（每日两次，40毫克、60毫克和80毫克）速尿的降压效果及其对血清钾和尿量的影响。该研究包括一个为期4周的安慰剂治疗期、三个为期6周的速尿治疗期以及一个为期4周的中间安慰剂期。平均动脉血压在最初2周内下降了约10 mmHg，且与速尿剂量无关。在接下来的治疗周内，血压持续缓慢下降。安慰剂期太短，数值无法恢复到初始水平。相比之下，尿量增加呈剂量依赖性，停药后尿量增加停止。利尿作用在整个治疗期内持续存在。血清钾下降与利尿作用之间存在相关性，而与血压下降无相关性。除血清锌显著增加外，未观察到其他电解质参数有变化。体重、脉搏、血红蛋白和红细胞沉降率保持不变。副作用较少且轻微，但倾向于随着剂量增加而增多。
