Department of Forensic Sciences, Section of Forensic Pathology and Clinical Forensic Medicine, Oslo University Hospital, Oslo, Norway.
The University of Adelaide, Adelaide, South Australia, Australia.
Acta Paediatr. 2024 Feb;113(2):249-255. doi: 10.1111/apa.16988. Epub 2023 Oct 4.
The aim of this study was to investigate a panel of immune proteins in cases of sudden infant death syndrome (SIDS). It was hypothesised that, in at least a subset of SIDS, a dysregulated immune response may be a contributing factor leading to death.
The subjects included 46 SIDS cases and 41 controls autopsied at the Department of Forensic Sciences, Norway. The causes of death in the controls were accidents/trauma. Samples of cerebrospinal fluid (CSF) were analysed quantitatively by Proximity Extension Assay (PEA).
Initial results revealed that normalised protein expression differed in 35 proteins. For the purposes of this report five proteins that are involved in immune system were selected for analysis: IFNLR1 (p = 0.003), IL10 (p = 0.007), IRAK4 (p < 0.001) and IL6 (p = 0.035); all had lower protein concentrations in SIDS cases compared to controls except for CD28 (p = 0.024) which had higher protein concentrations in SIDS cases.
The results confirm previous studies indicating that a dysregulation of the immune system may be a predisposing factor for SIDS. The results may indicate that these aberrant protein concentrations could lead to an inadequate response to immune triggers and uncontrolled defence mechanisms towards the common cold or other non-fatal infections.
本研究旨在探讨婴儿猝死综合征（SIDS）病例中的一组免疫蛋白。据推测，至少在 SIDS 的一部分病例中，免疫反应失调可能是导致死亡的一个促成因素。
本研究的研究对象包括在挪威法医学系进行尸检的 46 例 SIDS 病例和 41 例对照组。对照组的死因是意外/创伤。通过接近延伸分析（PEA）对脑脊液（CSF）样本进行定量分析。
初步结果显示，35 种蛋白质的归一化蛋白表达存在差异。为了本报告的目的，选择了涉及免疫系统的 5 种蛋白质进行分析：IFNLR1（p=0.003）、IL10（p=0.007）、IRAK4（p<0.001）和 IL6（p=0.035）；与对照组相比，SIDS 病例中的这些蛋白质浓度均较低，除 CD28（p=0.024）外，SIDS 病例中的 CD28 蛋白质浓度较高。
这些结果证实了先前的研究表明，免疫系统的失调可能是 SIDS 的一个易感因素。这些异常蛋白质浓度可能导致对免疫触发的反应不足和对普通感冒或其他非致命感染的失控防御机制。
