儿童和青少年镰状细胞病患者的最大鼻吸气流量：病例对照研究。
Peak nasal inspiratory flow in children and adolescents with sickle cell disease: a case-control study.
机构信息
Hemominas Foundation, Master's Degree in Pediatrics - Belo Horizonte (MG), Brazil.
University Hospital, Universidade Federal de Minas Gerais, Pediatric Pulmonology Unit - Belo Horizonte (MG), Brazil.
出版信息
Rev Assoc Med Bras (1992). 2023 Sep 25;69(10):e20210819. doi: 10.1590/1806-9282.20210819. eCollection 2023.
OBJECTIVE
Sickle cell disease is the most frequent of the hereditary hemoglobinopathies and it presents multisystemic effects. A manifestation that is commonly found in sickle cell disease is upper airway obstruction, particularly adenotonsillar hypertrophy. This study aims to evaluate the peak nasal inspiratory flow measurements of children and adolescents with sickle cell disease.
METHODS
This is a case-control study on children aged between 8 and 15 years who were diagnosed with sickle cell disease. Peak nasal inspiratory flow measurements were obtained from patients.
RESULTS
A total of 279 patients were enrolled in this study, with 93 in the case group and 186 in the control group. The case group had an 82.83% chance of having lower peak nasal inspiratory flow values than the control group. In the case group, 75% of the peak nasal inspiratory flow values were in the lower standards, whereas in the control group, only 25% were in the lower standards.
CONCLUSION
This study showed a high prevalence of reduced peak nasal inspiratory flow values in children with sickle cell disease and could certainly be incorporated into the day-to-day clinical evaluation of patients as a screening instrument.
目的
镰状细胞病是最常见的遗传性血红蛋白病，它具有多系统效应。镰状细胞病常见的表现之一是上呼吸道阻塞，特别是腺样体扁桃体肥大。本研究旨在评估镰状细胞病患儿的峰流速（PNIF）测量值。
方法
这是一项针对 8 至 15 岁确诊为镰状细胞病的儿童的病例对照研究。从患者中获得峰流速（PNIF）测量值。
结果
本研究共纳入 279 例患者，病例组 93 例，对照组 186 例。病例组的峰流速（PNIF）值低于对照组的可能性为 82.83%。在病例组中，75%的峰流速（PNIF）值处于较低标准，而在对照组中，只有 25%的峰流速（PNIF）值处于较低标准。
结论
本研究表明，镰状细胞病患儿的峰流速（PNIF）值降低的发生率较高，该结果可作为一种筛查工具纳入患者的日常临床评估中。
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