Department of Medical Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61‒614, Poznań, Poland.
Department of Medical Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61‒614, Poznań, Poland.
Eur J Med Chem. 2023 Dec 5;261:115838. doi: 10.1016/j.ejmech.2023.115838. Epub 2023 Sep 27.
Parasitic diseases still pose a serious threat to human and animal health, particularly for millions of people and their livelihoods in low-income countries. Therefore, research into the development of effective antiparasitic drugs remains a priority. Ivermectin, a sixteen-membered macrocyclic lactone, exhibits a broad spectrum of antiparasitic activities, which, combined with its low toxicity, has allowed the drug to be widely used in the treatment of parasitic diseases affecting humans and animals. In addition to its licensed use against river blindness and strongyloidiasis in humans, and against roundworm and arthropod infestations in animals, ivermectin is also used "off-label" to treat many other worm-related parasitic diseases, particularly in domestic animals. In addition, several experimental studies indicate that ivermectin displays also potent activity against viruses, bacteria, protozoans, trematodes, and insects. This review article summarizes the last 40 years of research on the antiparasitic effects of ivermectin, and the use of the drug in the treatment of parasitic diseases in humans and animals.
寄生虫病仍然严重威胁着人类和动物的健康，尤其是对低收入国家的数百万人及其生计构成威胁。因此，研究开发有效的抗寄生虫药物仍然是当务之急。伊维菌素是一种十六元大环内酯，具有广谱抗寄生虫活性，其低毒性使其在治疗影响人类和动物的寄生虫病方面得到广泛应用。除了在人类中用于治疗河盲症和旋毛虫病以及在动物中用于治疗线虫和节肢动物感染的许可用途外，伊维菌素还被“超适应证”用于治疗许多其他与蠕虫相关的寄生虫病，特别是在家畜中。此外，几项实验研究表明，伊维菌素对病毒、细菌、原生动物、吸虫和昆虫也具有很强的活性。本文综述了过去 40 年伊维菌素的抗寄生虫作用及其在人类和动物寄生虫病治疗中的应用。
