Gallo-Torres H E, Miller O N, Hamilton J G
Am J Clin Nutr. 1979 Jul;32(7):1363-75. doi: 10.1093/ajcn/32.7.1363.
Hypercholesterolemic subjects in a metabolic ward were kept under uniform dietary conditions until constant levels of serum cholesterol were observed. Oral dosage with deoxycholate (1.5 to 3 g daily for a period of 4 to 10 weeks) resulted in a marked reduction of serum cholesterol concentration. Studies with 14C-labeled cholesterol demonstrated that deoxycholate administration decreased absorption of cholesterol from the human intestinal tract. In these subjects, the turnover rate of serum cholesterol was more rapid during therapy with deoxycholate than during control periods. Deoxycholate appeared to influence the intestinal flora as assessed indirectly by analysis of the types of neutral sterols eliminated with the feces. Decreased synthesis of cholesterol during deoxycholate administration uas demonstrated in a study with 14C-mevalonate. It is concluded that deoxycholic acid can have an important role in the regulation of cholesterol metabolism in humans.
代谢病房中的高胆固醇血症患者被置于统一饮食条件下，直至观察到血清胆固醇水平恒定。口服脱氧胆酸盐（每日1.5至3克，持续4至10周）导致血清胆固醇浓度显著降低。用14C标记胆固醇的研究表明，给予脱氧胆酸盐会降低人体肠道对胆固醇的吸收。在这些患者中，脱氧胆酸盐治疗期间血清胆固醇的周转率比对照期更快。通过分析粪便中排出的中性固醇类型间接评估，脱氧胆酸盐似乎会影响肠道菌群。在一项用14C-甲羟戊酸进行的研究中证实，给予脱氧胆酸盐期间胆固醇合成减少。得出的结论是，脱氧胆酸在人体胆固醇代谢调节中可发挥重要作用。
