Department of Biostatistics and Health Informatics, King's College London, London, UK.
J Child Psychol Psychiatry. 2023 Dec;64(12):1765-1775. doi: 10.1111/jcpp.13892. Epub 2023 Oct 4.
The evidence base for interventions for child mental health and neurodevelopment is weak and the current capacity for rigorous evaluation limited. We describe some of the challenges that make this field particularly difficult and expensive for evaluation studies.
We describe and review the use of novel study designs and analysis methodology for their potential to improve this situation.
While several novel designs appeared ill-suited to our field, systematic review found others that offered potential but had yet to be widely adopted, some not at all.
While funding is inevitably a constraint, we argue that improvements in the evidence base of both current and new treatments will only be achieved by the adoption of a number of these new technologies and study designs, the consistent application of rigorous constructive but demanding standards, and the engagement of the public, patients, clinical and research services to build a design, recruitment, and analysis infrastructure.
干预儿童心理健康和神经发育的证据基础薄弱,目前严格评估的能力有限。我们描述了一些使该领域特别难以进行评估研究且成本高昂的挑战。
我们描述并回顾了新颖研究设计和分析方法的使用,以探讨它们改善这种情况的潜力。
虽然有几种新颖的设计似乎不适合我们的领域,但系统评价发现了其他具有潜力但尚未广泛采用的设计,有些则根本没有。
虽然资金不可避免地是一个限制因素,但我们认为,只有通过采用许多这些新技术和研究设计、一致应用严格的建设性但苛刻的标准以及让公众、患者、临床和研究服务参与来构建设计、招募和分析基础设施,才能改善现有和新治疗方法的证据基础。