Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada; Innovation and Portfolio Management, Canadian Blood Services, Edmonton, Alberta, Canada.
Transfus Apher Sci. 2023 Dec;62(6):103827. doi: 10.1016/j.transci.2023.103827. Epub 2023 Sep 29.
Donor sex can alter the RBC 'storage lesion' progression, contributing to dissimilarities in blood product quality, and thus adverse post-transfusion reactions. The mechanisms underlying the reduced sensitivity of female RBCs to storage-induced stress are partially ascribed to the differential effects of testosterone, progesterone, and estrogen on hemolytic propensity. Contributing to this is the increased proportion of more robust, biologically 'young' subpopulations of RBCs in females. Herein, we discuss the impact of sex hormones on RBCs and the relevance of these biological subpopulations to provide further insight into sex-dependent blood product variability.
供体性别可能会改变 RBC 的“储存损伤”进展，导致血液制品质量的差异，并因此产生不良的输血反应。女性 RBC 对储存引起的应激的敏感性降低的机制部分归因于睾酮、孕酮和雌激素对溶血倾向的不同影响。造成这种情况的原因是女性中更健壮、生物学上“年轻”的 RBC 亚群比例增加。本文讨论了性激素对 RBC 的影响以及这些生物学亚群的相关性，以进一步深入了解性别依赖性血液制品变异性。
