Tay D, So K F, Jen L S, Lau K C
Brain Res. 1986 Dec;395(2):268-73. doi: 10.1016/s0006-8993(86)80206-2.
The postnatal development of the optic nerve in the golden hamster has been examined using the electron microscope. The number of the optic fibres present in the optic nerve showed an initial increase during the first day after birth but it declined afterwards and tapered off after Day 16. At its peak on postnatal Day 1, there was an average of 314,629 axons in the optic nerve but when the animal reached adulthood only 109,587 fibres remained amounting to about 65% loss of the total fibre population. The period of axon loss coincided with the appearance of large patches of degenerated profiles in the optic nerve. The occurrence of the optic fibre loss has been implied to correlate with the time when the retinal projections were undergoing a dynamic reorganization at the target sites during the process of establishing the adult patterns of retinofugal connections.
利用电子显微镜对金黄仓鼠视神经的产后发育进行了研究。视神经中存在的视神经纤维数量在出生后的第一天开始时有所增加，但随后下降，并在第16天后逐渐减少。在出生后第1天达到峰值时，视神经中平均有314,629根轴突，但当动物成年时，仅剩下109,587根纤维，约占总纤维数量的65%。轴突损失的时期与视神经中大片退化形态的出现相吻合。视神经纤维损失的发生被认为与视网膜投射在建立成年视束连接模式的过程中在目标部位进行动态重组的时间相关。
