• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

出生后早期发育过程中大鼠视神经轴突的丧失。

Loss of axons from the optic nerve of the rat during early postnatal development.

作者信息

Lam K, Sefton A J, Bennett M R

出版信息

Brain Res. 1982 Mar;255(3):487-91. doi: 10.1016/0165-3806(82)90014-1.

DOI:10.1016/0165-3806(82)90014-1
PMID:7066702
Abstract

The number of axons in the optic nerve of the newborn rat has been compared with the number present in the adult animal. Nerves taken from animals on the day of birth contain 242,000 +/- 29,000 (S.D.) fibres (n = 5). By the sixth postnatal day, the number of axons has fallen to the stable values of adults (99,000 +/- 3700, n = 8). Thus development of the rat's visual system during the first 5 days of life is associated with a loss of 60% of the axons present in the optic nerve at birth. Counts made on the remaining nerve after enucleation of one eye suggest that the presence of retino-retinal axons during the first 5 postnatal days cannot account for all of this reduction.

摘要

已将新生大鼠视神经中的轴突数量与成年动物中的轴突数量进行了比较。出生当天取自动物的神经含有242,000±29,000(标准差)条纤维(n = 5)。到出生后第6天,轴突数量已降至成年动物的稳定值(99,000±3700,n = 8)。因此,大鼠视觉系统在出生后前5天的发育与出生时视神经中60%的轴突损失有关。对摘除一只眼睛后剩余神经进行的计数表明,出生后前5天视网膜-视网膜轴突的存在并不能解释所有这种减少。

相似文献

1
Loss of axons from the optic nerve of the rat during early postnatal development.出生后早期发育过程中大鼠视神经轴突的丧失。
Brain Res. 1982 Mar;255(3):487-91. doi: 10.1016/0165-3806(82)90014-1.
2
Quantitative and morphological studies on developing optic axons in normal and enucleated albino rats.正常和去眼球白化大鼠发育中视神经轴突的定量及形态学研究。
Exp Brain Res. 1984;57(1):107-17. doi: 10.1007/BF00231137.
3
Postnatal changes in retinal ganglion cell and optic axon populations in the pigmented rat.有色大鼠视网膜神经节细胞和视神经轴突群体的产后变化。
J Comp Neurol. 1983 Sep 20;219(3):356-68. doi: 10.1002/cne.902190309.
4
The postnatal development of the optic nerve of a reptile (Vipera aspis): A quantitative ultrastructural study.一种爬行动物(蝰蛇)视神经的产后发育:定量超微结构研究。
Anat Embryol (Berl). 2006 Nov;211(6):691-705. doi: 10.1007/s00429-006-0135-8. Epub 2006 Nov 3.
5
Changes in the numbers of optic nerve fibers during late prenatal and postnatal development in the albino rat.
Brain Res. 1985 Mar;351(1):129-34. doi: 10.1016/0165-3806(85)90238-x.
6
The postnatal development of the optic nerve in hamsters: an electron microscopic study.仓鼠视神经的产后发育:一项电子显微镜研究。
Brain Res. 1986 Dec;395(2):268-73. doi: 10.1016/s0006-8993(86)80206-2.
7
Numbers of axons in the optic nerve and of retinal ganglion cells during development in the marsupial Setonix brachyurus.
Brain Res. 1986 Feb;390(1):117-25. doi: 10.1016/0165-3806(86)90158-6.
8
Growth cones, dying axons, and developmental fluctuations in the fiber population of the cat's optic nerve.
J Comp Neurol. 1986 Apr 1;246(1):32-69. doi: 10.1002/cne.902460104.
9
The effect of intraocular tetrodotoxin on the postnatal reduction in the numbers of optic nerve axons in the rat.眼内注射河豚毒素对大鼠出生后视神经轴突数量减少的影响。
Brain Res. 1986 Nov;395(1):96-103. doi: 10.1016/s0006-8993(86)80014-2.
10
Inhibition of axoplasmic transport in the developing visual system of the rat-L Structural changes in the retina and optic nerve with graded doses of intraocular colchicine.大鼠发育中视觉系统轴浆运输的抑制——L 眼内给予不同剂量秋水仙碱后视网膜和视神经的结构变化
Neuroscience. 1982 Feb;7(2):365-84. doi: 10.1016/0306-4522(82)90273-1.

引用本文的文献

1
Microglia complement signaling promotes neuronal elimination and normal brain functional connectivity.小胶质细胞补体信号促进神经元消除和正常的大脑功能连接。
Cereb Cortex. 2023 Oct 14;33(21):10750-10760. doi: 10.1093/cercor/bhad313.
2
Tactile stimulation during development alters the neuroanatomical organization of the optic nerve in normal rats.发育过程中的触觉刺激会改变正常大鼠视神经的神经解剖结构。
Exp Brain Res. 2016 Jun;234(6):1737-46. doi: 10.1007/s00221-016-4586-8. Epub 2016 Feb 15.
3
The energetics of CNS white matter.中枢神经系统白质的能量学。
J Neurosci. 2012 Jan 4;32(1):356-71. doi: 10.1523/JNEUROSCI.3430-11.2012.
4
Group I metabotropic glutamate receptors (mGluRs) modulate visual responses in the superficial superior colliculus of the rat.I 型代谢型谷氨酸受体(mGluRs)调节大鼠上丘浅层的视觉反应。
J Physiol. 2002 Jun 15;541(Pt 3):895-903. doi: 10.1113/jphysiol.2002.016618.
5
Exposure of rats to a high but not low dose of ethanol during early postnatal life increases the rate of loss of optic nerve axons and decreases the rate of myelination.在出生后早期将大鼠暴露于高剂量而非低剂量乙醇中,会增加视神经轴突的丧失率,并降低髓鞘形成率。
J Anat. 2000 Oct;197 Pt 3(Pt 3):477-85. doi: 10.1046/j.1469-7580.2000.19730477.x.
6
Unilateral eye enucleation in adult rats causes neuronal loss in the contralateral superior colliculus.成年大鼠单侧眼球摘除会导致对侧上丘的神经元丢失。
J Anat. 1997 May;190 ( Pt 4)(Pt 4):481-90. doi: 10.1046/j.1469-7580.1997.19040481.x.
7
Postnatal development of the optic nerve in (C57BL x CBA)F1 hybrid mice: general changes in morphometric parameters.(C57BL×CBA)F1杂交小鼠视神经的出生后发育:形态学参数的一般变化
J Anat. 1996 Aug;189 ( Pt 1)(Pt 1):117-25.
8
Decreased axonal calibres without axonal loss in optic nerve following chronic alcohol feeding in adult rats: a morphometric study.
Acta Neuropathol. 1993;85(2):117-21. doi: 10.1007/BF00227757.
9
The survival of neonatal rat retinal ganglion cells in vitro is enhanced in the presence of appropriate parts of the brain.在存在大脑适当部分的情况下,新生大鼠视网膜神经节细胞在体外的存活率会提高。
Exp Brain Res. 1982;48(3):377-86. doi: 10.1007/BF00238614.
10
Activity and the control of ganglion cell death in the rat retina.
Proc Natl Acad Sci U S A. 1984 Sep;81(17):5589-93. doi: 10.1073/pnas.81.17.5589.