微环境 GABA 信号通过黑色素瘤-角质形成细胞的相互通讯调节黑色素瘤发生。
Microenvironmental GABA Signaling Regulates Melanomagenesis through Reciprocal Melanoma-Keratinocyte Communication.
机构信息
Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts.
Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts.
出版信息
Cancer Discov. 2023 Oct 5;13(10):2128-2130. doi: 10.1158/2159-8290.CD-23-0843.
Abstract
GABA signaling by melanoma cells was found by Tagore and colleagues to trigger keratinocyte-driven growth of melanomas. This study reveals new roles for nonneuronal signaling by a neurotransmitter in regulating tumor initiation and outgrowth. See related article by Tagore et al., p. 2270 (4).
摘要
Tagore 及其同事发现黑色素瘤细胞的 GABA 信号会触发角质形成细胞驱动黑色素瘤的生长。这项研究揭示了神经递质的非神经元信号在调节肿瘤起始和生长中的新作用。参见 Tagore 等人的相关文章，第 2270 页（4）。
相似文献
1
Microenvironmental GABA Signaling Regulates Melanomagenesis through Reciprocal Melanoma-Keratinocyte Communication.微环境 GABA 信号通过黑色素瘤-角质形成细胞的相互通讯调节黑色素瘤发生。
Cancer Discov. 2023 Oct 5;13(10):2128-2130. doi: 10.1158/2159-8290.CD-23-0843.
2
GABA Regulates Electrical Activity and Tumor Initiation in Melanoma.GABA 调节黑色素瘤中的电活动和肿瘤起始。
Cancer Discov. 2023 Oct 5;13(10):2270-2291. doi: 10.1158/2159-8290.CD-23-0389.
3
Heterozygous loss of keratinocyte TRIM16 expression increases melanocytic cell lesions and lymph node metastasis.角质形成细胞 TRIM16 表达的杂合缺失增加黑素细胞病变和淋巴结转移。
J Cancer Res Clin Oncol. 2019 Sep;145(9):2241-2250. doi: 10.1007/s00432-019-02981-5. Epub 2019 Jul 24.
4
UV-Induced Molecular Signaling Differences in Melanoma and Non-melanoma Skin Cancer.紫外线诱导的黑色素瘤和非黑色素瘤皮肤癌中的分子信号差异
Adv Exp Med Biol. 2017;996:27-40. doi: 10.1007/978-3-319-56017-5_3.
5
UV and melanoma: the TP53 link.紫外线与黑色素瘤：TP53 关联
Cell Res. 2014 Oct;24(10):1157-8. doi: 10.1038/cr.2014.95. Epub 2014 Jul 18.
6
E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors.黑色素瘤细胞中E-钙黏蛋白的表达可恢复角质形成细胞介导的生长控制，并下调侵袭相关黏附受体的表达。
Am J Pathol. 2000 May;156(5):1515-25. doi: 10.1016/S0002-9440(10)65023-7.
7
NUAK2: an emerging acral melanoma oncogene.NUAK2：一种新出现的肢端黑色素瘤致癌基因。
Oncotarget. 2011 Sep;2(9):695-704. doi: 10.18632/oncotarget.325.
8
Contribution of Keratinocytes in Skin Cancer Initiation and Progression.角质形成细胞在皮肤癌发生和进展中的作用。
Int J Mol Sci. 2024 Aug 13;25(16):8813. doi: 10.3390/ijms25168813.
9
Melanoma cells repress Desmoglein 1 in keratinocytes to promote tumor cell migration.黑素瘤细胞在角质细胞中抑制桥粒芯糖蛋白 1 以促进肿瘤细胞迁移。
J Cell Biol. 2023 Nov 6;222(11). doi: 10.1083/jcb.202212031. Epub 2023 Sep 21.
10
Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis in vivo.间隙连接蛋白 43 可减少角质形成细胞微环境中的黑素瘤生长和体内肿瘤发生。
J Biol Chem. 2014 Jan 17;289(3):1592-603. doi: 10.1074/jbc.M113.507228. Epub 2013 Dec 2.
引用本文的文献
1
GABRD Accelerates Tumour Progression via Regulating CCND1 Signalling Pathway in Gastric Cancer.GABRD通过调控胃癌中的CCND1信号通路加速肿瘤进展。
J Cell Mol Med. 2025 Apr;29(7):e70485. doi: 10.1111/jcmm.70485.
本文引用的文献
1
GABA Regulates Electrical Activity and Tumor Initiation in Melanoma.GABA 调节黑色素瘤中的电活动和肿瘤起始。
Cancer Discov. 2023 Oct 5;13(10):2270-2291. doi: 10.1158/2159-8290.CD-23-0389.
2
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth.不断演变的肿瘤微环境：从癌症起始到转移灶生长
Cancer Cell. 2023 Mar 13;41(3):374-403. doi: 10.1016/j.ccell.2023.02.016.
3
Pitfalls in Cutaneous Melanoma Diagnosis and the Need for New Reliable Markers.皮肤黑色素瘤诊断中的陷阱及对新型可靠标志物的需求
Mol Diagn Ther. 2023 Jan;27(1):49-60. doi: 10.1007/s40291-022-00628-9. Epub 2022 Dec 7.
4
Micro-environment alterations through time leading to myeloid malignancies.随着时间的推移导致髓系恶性肿瘤的微环境改变。
Br J Pharmacol. 2024 Jan;181(2):283-294. doi: 10.1111/bph.15924. Epub 2022 Jul 31.
5
A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity.肝脏γ-氨基丁酸在肥胖的代谢功能障碍和食欲亢进中起关键作用。
Cell Rep. 2021 Jun 29;35(13):109301. doi: 10.1016/j.celrep.2021.109301.
6
Participation of keratinocyte- and fibroblast-derived factors in melanocyte homeostasis, the response to UV, and pigmentary disorders.角质形成细胞和成纤维细胞来源的因子在黑素细胞稳态、对 UV 的反应和色素障碍中的作用。
Pigment Cell Melanoma Res. 2021 Jul;34(4):762-776. doi: 10.1111/pcmr.12985. Epub 2021 May 24.
7
The future of cancer immunotherapy: microenvironment-targeting combinations.癌症免疫疗法的未来：靶向微环境的联合疗法。
Cell Res. 2020 Jun;30(6):507-519. doi: 10.1038/s41422-020-0337-2. Epub 2020 May 28.
8
Neuronal Activity in Ontogeny and Oncology.个体发育与肿瘤学中的神经元活动
Trends Cancer. 2017 Feb;3(2):89-112. doi: 10.1016/j.trecan.2016.12.008. Epub 2017 Feb 13.
9
GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes.GABA 对胰岛β细胞具有保护和再生作用，并可逆转糖尿病。
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11692-7. doi: 10.1073/pnas.1102715108. Epub 2011 Jun 27.
10
E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors.黑色素瘤细胞中E-钙黏蛋白的表达可恢复角质形成细胞介导的生长控制，并下调侵袭相关黏附受体的表达。
Am J Pathol. 2000 May;156(5):1515-25. doi: 10.1016/S0002-9440(10)65023-7.
Zotero 插件