Université de Toulouse, Inserm, CNRS, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, 31037 Toulouse, France.
Int J Mol Sci. 2024 Aug 13;25(16):8813. doi: 10.3390/ijms25168813.
Keratinocytes are major cellular components of the skin and are strongly involved in its homeostasis. Oncogenic events, starting mainly from excessive sun exposure, lead to the dysregulation of their proliferation and differentiation programs and promote the initiation and progression of non-melanoma skin cancers (NMSCs). Primary melanomas, which originate from melanocytes, initiate and develop in close interaction with keratinocytes, whose role in melanoma initiation, progression, and immune escape is currently being explored. Recent studies highlighted, in particular, unexpected modes of communication between melanocytic cells and keratinocytes, which may be of interest as sources of new biomarkers in melanomagenesis or potential therapeutic targets. This review aims at reporting the various contributions of keratinocytes in skin basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC), and melanoma, with a greater focus on the latter in order to highlight some recent breakthrough findings. The readers are referred to recent reviews when contextual information is needed.
角质形成细胞是皮肤的主要细胞成分，强烈参与其体内平衡。致癌事件主要始于过度暴露于阳光下，导致其增殖和分化程序失调，并促进非黑素瘤皮肤癌 (NMSC) 的发生和进展。原发性黑素瘤起源于黑素细胞，在与角质形成细胞的密切相互作用下启动和发展，角质形成细胞在黑素瘤的启动、进展和免疫逃逸中的作用目前正在探索中。最近的研究特别强调了黑素细胞和角质形成细胞之间出乎意料的通讯模式，这些模式可能作为黑素瘤发生或潜在治疗靶点的新生物标志物的来源而引起关注。本综述旨在报告角质形成细胞在皮肤基底细胞癌 (BCC)、皮肤鳞状细胞癌 (cSCC) 和黑色素瘤中的各种贡献，重点介绍后者，以突出一些最近的突破性发现。当需要上下文信息时，请读者参考最近的评论。
