Abdulatif M, Naguib M
Can Anaesth Soc J. 1986 Nov;33(6):723-8. doi: 10.1007/BF03027121.
The hypothesis that administration of neostigmine in divided doses might accelerate the antagonism of neuromuscular blockade was investigated. Neostigmine 0.05 mg X kg-1 was administered either in a single bolus dose (Group I, n = 16) or in an initial dose of 0.01 mg X kg-1 followed three minutes later by 0.04 mg X kg-1 (Group II, n = 16) for antagonism of atracurium-induced blockade. Reversal was attempted at 10 per cent spontaneous recovery of twitch height. The mean time (+/- SD) from the first injection of the drug until the train-of-four (TOF) ratio value had reached 0.75 was significantly shorter in Group II (p less than 0.05) than in Group I (391.8 +/- 83.3 and 468.6 +/- 150.3 seconds respectively). The rate of TOF ratio recovery was 2.5 times faster after neostigmine administration in divided doses. It is concluded that administration of neostigmine in divided doses, as described in this study, produced a significantly faster reversal of residual atracurium-induced neuromuscular blockade as compared to a single bolus administration.
研究了分次给予新斯的明是否可能加速神经肌肉阻滞的拮抗作用这一假说。给予0.05mg·kg-1新斯的明，要么单次静脉推注（I组，n = 16），要么先给予初始剂量0.01mg·kg-1，3分钟后再给予0.04mg·kg-1（II组，n = 16），用于拮抗阿曲库铵诱导的阻滞。当颤搐高度自发恢复至10%时尝试进行逆转。从首次注射药物至四个成串刺激（TOF）比值达到0.75的平均时间（±标准差），II组（p<0.05）显著短于I组（分别为391.8±83.3秒和468.6±150.3秒）。分次给予新斯的明后TOF比值恢复速率快2.5倍。得出结论，如本研究所述，与单次静脉推注相比，分次给予新斯的明能显著更快地逆转残余阿曲库铵诱导的神经肌肉阻滞。
