新斯的明和依酚氯铵作为阿曲库铵和泮库溴铵的拮抗剂。

Neostigmine and edrophonium as antagonists of atracurium and pancuronium.

作者信息

Sanfilippo M, Vilardi V, Fierro G, Rosa G, Pelaia P, Gasparetto A

机构信息

Department of Anaesthesiology and Intensive Care, State University La Sapienza, Rome, Italy.

出版信息

Acta Anaesthesiol Scand. 1988 Aug;32(6):437-40. doi: 10.1111/j.1399-6576.1988.tb02762.x.

DOI:10.1111/j.1399-6576.1988.tb02762.x

PMID:2845694

Abstract

Edrophonium 0.5 mg/kg or neostigmine 0.04 mg/kg were administered to two groups of 30 patients each for antagonism of atracurium- or pancuronium-induced neuromuscular block at 25% single twitch recovery. Neuromuscular block was studied using both single twitch and train-of-four (TOF) nerve stimulation. The times to 100% single twitch recovery were significantly more rapid for patients receiving edrophonium (P less than 0.01) in both groups (atracurium and pancuronium); the TOF ratios were similar for atracurium, but for pancuronium they were greater after neostigmine than after edrophonium, and only at 25 min were these ratios similar. It is concluded that edrophonium in a dose of 0.5 mg/kg antagonizes neuromuscular blockade induced by atracurium, as does neostigmine in a dose of 0.04 mg/kg, but the former does not consistently antagonize neuromuscular blockade induced by pancuronium even at 25% of single twitch recovery.

摘要

将两组各30例患者分别给予依酚氯铵0.5mg/kg或新斯的明0.04mg/kg，用于拮抗阿曲库铵或泮库溴铵诱导的神经肌肉阻滞，使其达到单次颤搐恢复25%。使用单次颤搐和四个成串刺激（TOF）神经刺激来研究神经肌肉阻滞。在两组（阿曲库铵组和泮库溴铵组）中，接受依酚氯铵的患者达到100%单次颤搐恢复的时间明显更快（P<0.01）；阿曲库铵组的TOF比值相似，但对于泮库溴铵组，新斯的明给药后的TOF比值高于依酚氯铵给药后，仅在25分钟时这些比值相似。得出结论，0.5mg/kg剂量的依酚氯铵可拮抗阿曲库铵诱导的神经肌肉阻滞，0.04mg/kg剂量的新斯的明也可如此，但前者即使在单次颤搐恢复25%时也不能始终拮抗泮库溴铵诱导的神经肌肉阻滞。