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吲哚生物碱的化学反应,可快速获得用于发现的新骨架。

Chemical Reactions of Indole Alkaloids That Enable Rapid Access to New Scaffolds for Discovery.

作者信息

Leas Derek A, Schultz Daniel C, Huigens Robert W

机构信息

Department of Medicinal Chemistry, Center for Natural Products Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.

出版信息

SynOpen. 2023 Jun;7(2):165-185. doi: 10.1055/a-2048-8412. Epub 2023 May 11.

Abstract

This graphical review provides a concise overview of indole alkaloids and chemical reactions that have been reported to transform both these natural products and derivatives to rapidly access new molecular scaffolds. Select biologically active compounds from these synthetic efforts are reported herein.

摘要

本图形综述简要概述了吲哚生物碱以及据报道可将这些天然产物及其衍生物进行转化以快速获得新分子骨架的化学反应。本文报道了这些合成研究中具有生物活性的化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab0/10549995/796f785927f3/nihms-1932741-f0005.jpg

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