Brook I, Walker R I, MacVittie T J
Can J Microbiol. 1986 Sep;32(9):719-22. doi: 10.1139/m86-130.
The presence of aerobic and anaerobic bacteria in the blood, spleen, and liver was investigated in mice that were exposed to 7, 8, 9, or 10 Gy 60Co radiation. Microorganisms were detected more often in animals exposed to higher doses of radiation. The number of mice that were culture positive and the number of isolates in one site increased with increasing dose. Bacteria were recovered in mice killed at various times after radiation, in 3 of 100 mice exposed to 7 Gy, in 13 of 100 irradiated with 8 Gy, in 23 of 90 exposed to 9 Gy, and in 34 of 87 irradiated with 10 Gy. The predominant organisms recovered were Escherichia coli, anaerobic Gram-positive cocci, Proteus mirabilis, Staphylococcus aureus, and Bacteroides spp. Escherichia coli and anaerobes were more often isolated in animals exposed to 10 Gy, while S. aureus was more often recovered in those irradiated with 9 Gy. These data demonstrate a relationship between the dose of radiation and the rate of infection due to enteric aerobic and anaerobic bacteria.
在接受7、8、9或10 Gy 60Co辐射的小鼠中，研究了血液、脾脏和肝脏中需氧菌和厌氧菌的存在情况。在接受较高剂量辐射的动物中，微生物的检出频率更高。培养呈阳性的小鼠数量以及单个部位的分离菌数量随剂量增加而增加。在辐射后不同时间处死的小鼠中均回收了细菌，在接受7 Gy辐射的100只小鼠中有3只，在接受8 Gy辐射的100只中有13只，在接受9 Gy辐射的90只中有23只，在接受10 Gy辐射的87只中有34只。回收的主要微生物为大肠杆菌、厌氧革兰氏阳性球菌、奇异变形杆菌、金黄色葡萄球菌和拟杆菌属。在接受10 Gy辐射的动物中，大肠杆菌和厌氧菌的分离频率更高，而在接受9 Gy辐射的动物中，金黄色葡萄球菌的回收频率更高。这些数据证明了辐射剂量与肠道需氧菌和厌氧菌引起的感染率之间的关系。
