Department of Obstetrics and Gynecology, National Taiwan University Hospital, Hsinchu, Taiwan.
Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
Front Endocrinol (Lausanne). 2023 Sep 15;14:1223181. doi: 10.3389/fendo.2023.1223181. eCollection 2023.
The failure of remodeling the spiral arteries is associated with the pathogenesis of preeclampsia. Estradiol (E2) plays a crucial role in placentation and may be involved in the development of preeclampsia. However, there is a lack of data in this area. This study aims to assess the association between serum estradiol levels in early pregnancy and the risk of preeclampsia.
We conducted a retrospective cohort study on patients who conceived after frozen embryo transfer (FET) using data from a database at a university-affiliated fertilization center. The study period spanned from January 1, 2010, to December 31, 2020. Multivariable logistic regression analyses were performed to determine the adjusted effect of E2 levels on the risk of preeclampsia. We compared the odds ratios of preeclampsia across quartiles of E2 levels and assessed their significance.
Serum E2 levels at the fifth gestational week were significantly different between women with and without preeclampsia after FET programmed cycles (607.5 ± 245.4 vs. 545.6 ± 294.4 pg/ml, p=0.009). A multivariable logistic regression model demonstrated that E2 levels in early pregnancy were independent risk factors for preeclampsia. We observed an increased odds ratio of preeclampsia with increasing quartiles of estradiol levels after adjusting for potential confounders in FET programmed cycles. When comparing quartiles 3 and 4 (E2 > 493 pg/ml at the fifth gestational week) to quartiles 1 and 2, the odds ratios of preeclampsia were significantly higher.
We found that serum E2 levels in early pregnancy may impact the risk of preeclampsia, particularly following FET programmed cycles. The association between E2 levels in early pregnancy and preeclampsia deserves further investigation.
螺旋动脉重塑失败与子痫前期的发病机制有关。雌二醇（E2）在胎盘形成中起着至关重要的作用，并且可能与子痫前期的发生有关。然而，在这方面的数据还很缺乏。本研究旨在评估早孕期血清雌二醇水平与子痫前期风险之间的关系。
我们使用大学附属医院的一个受精中心数据库中的数据，对接受冻融胚胎移植（FET）后妊娠的患者进行了一项回顾性队列研究。研究期间为 2010 年 1 月 1 日至 2020 年 12 月 31 日。采用多变量逻辑回归分析来确定 E2 水平对子痫前期风险的调整作用。我们比较了 E2 水平四分位数之间子痫前期的比值比，并评估了它们的显著性。
FET 程控周期后发生子痫前期的妇女与未发生子痫前期的妇女在第五孕周的血清 E2 水平有显著差异（607.5±245.4 与 545.6±294.4 pg/ml，p=0.009）。多变量逻辑回归模型表明，早孕期 E2 水平是子痫前期的独立危险因素。我们观察到，在调整 FET 程控周期中的潜在混杂因素后，随着 E2 水平四分位数的升高，子痫前期的发生比值比增加。当比较第 3 和第 4 四分位数（第 5 孕周 E2>493 pg/ml）与第 1 和第 2 四分位数时，子痫前期的发生比值比显著更高。
我们发现早孕期血清 E2 水平可能影响子痫前期的风险，尤其是在 FET 程控周期后。早孕期 E2 水平与子痫前期之间的关联值得进一步研究。
