Department of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, 1300 Morris Park Ave Block 634, Bronx, NY, 10461, USA.
J Assist Reprod Genet. 2017 Dec;34(12):1633-1638. doi: 10.1007/s10815-017-1016-1. Epub 2017 Aug 19.
The aim of this study is to evaluate the correlation between serum estradiol (E) levels during artificial autologous frozen embryo transfer (FET) cycles and ongoing pregnancy/live birth rates (OP/LB).
A historical cohort study was conducted in an academic setting in order to correlate peak and average estradiol levels with ongoing pregnancy/live birth rates for all autologous artificial frozen embryo transfer cycles performed from 1/2011 to 12/2014.
Average and peak E levels from 110 autologous artificial FET cycles from 95 patients were analyzed. Average E levels were significantly lower in cycles resulting in OP/LB compared to those that did not (234.1 ± 16.6 pg/ml vs. 315 ± 24.8 pg/ml, respectively, p = 0.04). Although peak E levels were not significantly different between cycles resulting in OP/LB compared with those that did not (366.9 ± 27.7 pg/ml vs. 459.1 ± 32.3 pg/ml, respectively, p = 0.19), correlation analysis revealed a statistically significant (p = 0.02) downward trend in OP/LB rates with increasing peak E levels.
This study suggests that elevated E levels in artificial autologous FET cycles are associated with lower OP/LB rates. Estradiol levels should be monitored during artificial FET cycles.
本研究旨在评估人工自体冻融胚胎移植（FET）周期中血清雌二醇（E）水平与持续妊娠/活产率（OP/LB）之间的相关性。
本研究为回顾性队列研究，在学术环境中进行，以分析 2011 年 1 月至 2014 年 12 月期间进行的所有自体人工冻融胚胎移植周期的峰值和平均雌二醇水平与持续妊娠/活产率的相关性。
分析了 95 名患者的 110 个自体人工 FET 周期的平均和峰值 E 水平。与未获得 OP/LB 的周期相比，获得 OP/LB 的周期的平均 E 水平显著降低（分别为 234.1±16.6 pg/ml 和 315±24.8 pg/ml，p=0.04）。虽然获得 OP/LB 的周期的峰值 E 水平与未获得 OP/LB 的周期无显著差异（分别为 366.9±27.7 pg/ml 和 459.1±32.3 pg/ml，p=0.19），但相关性分析显示，随着峰值 E 水平的升高，OP/LB 率呈统计学显著下降趋势（p=0.02）。
本研究表明，人工自体 FET 周期中升高的 E 水平与较低的 OP/LB 率相关。应在人工 FET 周期中监测雌二醇水平。
