Kotit Susy, Yacoub Magdi H
Aswan Heart Centre, Aswan, Egypt.
Heart Science Centre, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Front Cardiovasc Med. 2023 Sep 18;10:1230965. doi: 10.3389/fcvm.2023.1230965. eCollection 2023.
Rheumatic Heart Disease (RHD) remains a major cause of valvular heart disease related mortality and morbidity in low- and middle-income countries, with significant variation in characteristics and course of the disease across different regions. However, despite the high disease burden, there is sparse region-specific data on demographics, disease characteristics and course in treated and untreated patients to guide policy.
The ARGI database is a hospital-based registry in a tertiary referral national centre (Aswan Heart Centre, AHC) in which all patients with the diagnosis of RHD are being included. The mode of presentation, including baseline clinical and echocardiographic characteristics (as well as other imaging modalities), biomarkers and genetics are being documented. Treatment modalities and adherence to treatment is being recorded and patients are followed up regularly every 6 and/or 12 months, or more frequently if needed.
This study shows for the first time an in-depth analysis of the severity and phenotype of disease in Egyptian patients presenting with RHD as well as the progression with time and provides a platform for further comparisons of regional differences in these details as well as their causes. The ARGI database will be of help in achieving the objectives of the Cairo Accord aiming at eradication of RF and RHD.
在低收入和中等收入国家，风湿性心脏病（RHD）仍是瓣膜性心脏病相关死亡率和发病率的主要原因，不同地区的疾病特征和病程存在显著差异。然而，尽管疾病负担沉重，但关于接受治疗和未接受治疗患者的人口统计学、疾病特征和病程的区域特定数据却很稀少，无法为政策提供指导。
ARGI数据库是一个位于三级转诊国家中心（阿斯旺心脏中心，AHC）的基于医院的登记系统，所有诊断为RHD的患者均被纳入。记录了就诊方式，包括基线临床和超声心动图特征（以及其他影像学检查方式）、生物标志物和遗传学信息。记录治疗方式和治疗依从性，患者每6个月和/或12个月定期随访，如有需要随访更频繁。
本研究首次对埃及RHD患者的疾病严重程度和表型以及随时间的进展进行了深入分析，并为进一步比较这些细节的区域差异及其原因提供了一个平台。ARGI数据库将有助于实现旨在消除风湿热和RHD的《开罗协议》的目标。
