铑催化苯胺与碳酸亚乙烯酯的C-H羧甲基化反应
Rhodium-catalyzed C-H carboxymethylation of anilines with vinylene carbonate.
作者信息
Liu Qiong, Ma Zhaolong, Zhang Jing, Li Xu-Qin
机构信息
School of Chemical and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China.
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, P. R. China.
出版信息
Org Biomol Chem. 2023 Oct 25;21(41):8320-8328. doi: 10.1039/d3ob00931a.
A rhodium-catalyzed synthesis of phenylacetate has been realized by direct C-H carboxymethylation of anilines bearing removable directing groups. The reaction occurred most efficiently in air, without any external base or oxidant. This methodology is expected to provide a facile and general access to various bioactive 2-amino aromatic acetic acid derivatives.
通过对带有可除去导向基团的苯胺进行直接C-H羧甲基化反应，实现了铑催化的苯乙酸酯合成。该反应在空气中能最有效地进行，无需任何外部碱或氧化剂。预计该方法能为各种生物活性2-氨基芳基乙酸衍生物提供一种简便通用的合成途径。
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