从调控到毁灭：一种流氓σ因子导致 细胞死亡。
From regulation to ruin: a rogue sigma factor causes cell death in .
机构信息
Department of Biological Sciences, Mount Holyoke College , South Hadley, Massachusetts, USA.
Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa , Iowa City, Iowa, USA.
出版信息
J Bacteriol. 2023 Oct 26;205(10):e0020323. doi: 10.1128/jb.00203-23. Epub 2023 Oct 5.
Abstract
A rogue, plasmid-encoded sigma factor that kills is the focus of a new study by A. T. Burton, D. Pospíšilová, P. Sudzinová, E. V. Snider, A. M. Burrage, L. Krásný, and D. B. Kearns (J Bacteriol 205:e00112-23, 2023, https://doi.org/10.1128/jb.00112-23). The authors demonstrate that SigN is toxic in its own right, causing cell death by potently outcompeting the housekeeping sigma factor for access to RNA polymerase.
摘要
一个流氓，质粒编码的 σ 因子，杀死 是由 A. T. Burton、D. Pospíšilová、P. Sudzinová、E. V. Snider、A. M. Burrage、L. Krásný 和 D. B. Kearns（J Bacteriol 205:e00112-23, 2023, https://doi.org/10.1128/jb.00112-23）的一项新研究的焦点。作者证明 SigN 本身具有毒性，通过强烈竞争管家 σ 因子来获得 RNA 聚合酶，从而导致细胞死亡。
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