Medjedded Housna, Nemiche Souhila, Nemmiche Saïd
Department of Biology, Faculty of Nature and Life Sciences, University of Mostaganem, Mostaganem, Algeria.
Department of Biology, Faculty of Nature and Life Sciences, University of Oran 1, Oran, Algeria.
Int J Environ Health Res. 2024 Jul;34(7):2649-2660. doi: 10.1080/09603123.2023.2265310. Epub 2023 Oct 5.
The exposure of humans and animals to environmental compounds is rarely restricted to a single chemical. Cadmium (Cd) and lead (Pb) are two heavy metals known to be the most toxic. Deleterious effects of each metal alone are well documented. Unfortunately, very few studies were conducted to determine their combined effect. Four groups of Wistar rats were treated intravenously for 15 days. The control group received physiological saline solution; groups 2 and 3 were treated with Cd chloride and lead acetate, respectively ; and the treatment group 4 received a combined treatment of Cd and Pb . A significant decrease was recorded for hematological parameters , with an increase in white blood cells and an inhibition in -ALAD level. Cell injury in the livers and kidneys was clearly shown by the significant elevation of the biochemical markers. Cd and Pb induced oxidative stress and had adverse health effects at lower exposure levels than previously thought.
人类和动物接触环境化合物的情况很少局限于单一化学物质。镉（Cd）和铅（Pb）是已知毒性最强的两种重金属。每种金属单独产生的有害影响都有充分记录。遗憾的是，很少有研究来确定它们的联合效应。将四组Wistar大鼠静脉注射给药15天。对照组接受生理盐水溶液；第2组和第3组分别用氯化镉和醋酸铅进行处理；第4组治疗组接受镉和铅的联合处理。血液学参数显著下降，白细胞增加，δ-氨基乙酰丙酸脱水酶（ALAD）水平受到抑制。肝脏和肾脏中的细胞损伤通过生化标志物的显著升高明显表现出来。镉和铅在比先前认为的更低暴露水平下就会诱导氧化应激并对健康产生不良影响。
