Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Eur J Pharmacol. 2023 Dec 5;960:176063. doi: 10.1016/j.ejphar.2023.176063. Epub 2023 Oct 4.
Alongside the conventional methods, attention has been drawn to the use of immunotherapy-based methods for cancer treatment. Immunotherapy has developed as a therapeutic option that can be more specific with better outcomes in tumor treatment. It can boost or regulate the immune system behind the targeted virotherapy. Virotherapy is a kind of oncolytic immunotherapy that investigated broadly in cancer treatment in recent decades, due to its several advantages. According to recent advance in the field of understanding cancer cell biology and its occurrence, as well as increasing the knowledge about conditionally replicating oncolytic viruses and their destructive function in the tumor cells, nowadays, it is possible to apply this strategy in the treatment of malignancies. Relying on achievements in clinical trials of oncolytic viruses, we can certainly expect that this therapeutic perception can play a more central role in cancer treatment. In cancer treatment, combination therapy using oncolytic viruses alongside standard cancer treatment methods and other immunotherapy-based treatments can expect more promising results in the future.
除了传统方法外，人们还关注利用基于免疫疗法的方法治疗癌症。免疫疗法已经发展成为一种治疗选择，在肿瘤治疗中可以更具针对性，效果更好。它可以增强或调节靶向病毒疗法背后的免疫系统。病毒疗法是一种溶瘤免疫疗法，近几十年来在癌症治疗中得到了广泛研究，因为它具有多种优势。根据近年来在理解癌细胞生物学及其发生方面的进展，以及对条件复制溶瘤病毒及其在肿瘤细胞中的破坏功能的了解不断增加，如今，这种策略可以应用于恶性肿瘤的治疗。基于溶瘤病毒临床试验的成果，我们当然可以预期这种治疗方法可以在癌症治疗中发挥更核心的作用。在癌症治疗中，溶瘤病毒与标准癌症治疗方法和其他基于免疫疗法的治疗方法联合使用，未来可能会取得更有前景的结果。
