Department of Ophthalmology, Antalya Education and Research Hospital, University of Health Sciences, Antalya, Turkey.
Department of General Surgery, Antalya Education and Research Hospital, University of Health Sciences, Antalya, Turkey.
Photodiagnosis Photodyn Ther. 2023 Dec;44:103826. doi: 10.1016/j.pdpdt.2023.103826. Epub 2023 Oct 4.
To evaluate optic disc and retinal vascular densities in obese patients using optical coherence tomography angiography (OCTA).
This study included 27 eyes from 27 obese patients with a body mass index (BMI) of ≥35 who were scheduled for bariatric surgery at the general surgery clinic and 26 eyes from 26 healthy individuals with a BMI of 18.5-24.9 kg/m who were of similar age and gender to the obese group. The macular vascular densities of the superficial and deep capillary plexuses (SCP and DCP, respectively), choriocapillaris flow area, optic disc peripapillary vascular density, and retinal thicknesses were evaluated using the OCTA device in obese patients and controls.
The mean age of the obese patients was 35.89 ± 10.93 years, and that of the controls was 32.31 ± 7.88 years (p = 0.199). The mean BMI values of the obese and control groups were 45.04 ± 6.89 kg/m and 23.19 ± 1.66 kg/m, respectively (p < 0.0001). The whole, parafoveal, and perifoveal vascular density values of the SCP and those of the DCP were statistically significantly lower in the obese group than in the control group (p = 0.004, p = 0.011, p = 0.006, p = 0.036, p = 0.029, and p = 0.024, respectively). There was no significant difference between the two groups in terms of optic disc vascular density. Full retinal perifoveal thickness, full retinal perifoveal volume, inner retinal perifoveal thickness, and inner retinal perifoveal volume were statistically significantly lower in obese patients compared to the controls (p = 0.043, p = 0.042, p = 0.027, and p = 0.024, respectively). In addition, statistically significant negative correlations were found between BMI and the whole, parafoveal, and perifoveal vascular densities of the SCP and DCP and the whole vascular density values of the optic disc for all vessels and small vessels (p = 0.017, r = -0.327; p = 0.043, r = -0.280; p = 0.033, r = -0.293; p = 0.034, r = -0.291; p = 0.017, r = -0.327; p = 0.023, r = -0.311; p = 0.031, r = -0.296; and p = 0.047, r = -0.274, respectively).
We consider that the decrease in retinal vascular density and retinal thickness in obese patients is responsible for obesity-induced oxidative stress, increased inflammatory cytokines, and microvascular damage.
利用光相干断层扫描血管造影术（OCTA）评估肥胖患者的视盘和视网膜血管密度。
本研究纳入了 27 名肥胖患者（BMI≥35）的 27 只眼和 26 名 BMI 为 18.5-24.9 kg/m²的健康个体（BMI<35）的 26 只眼，这些个体的年龄和性别与肥胖组相匹配。使用 OCTA 设备评估肥胖患者和对照组的黄斑浅层毛细血管丛（SCP）和深层毛细血管丛（DCP）、脉络膜毛细血管血流面积、视盘周围血管密度和视网膜厚度的血管密度。
肥胖患者的平均年龄为 35.89±10.93 岁，对照组为 32.31±7.88 岁（p=0.199）。肥胖组和对照组的平均 BMI 值分别为 45.04±6.89 kg/m²和 23.19±1.66 kg/m²（p<0.0001）。SCP 的全层、旁黄斑和中心凹下血管密度值和 DCP 的全层、旁黄斑和中心凹下血管密度值在肥胖组中均显著低于对照组（p=0.004，p=0.011，p=0.006，p=0.036，p=0.029，p=0.024，分别）。两组之间视盘血管密度无显著差异。肥胖患者的全视网膜旁黄斑厚度、全视网膜旁黄斑容积、内视网膜旁黄斑厚度和内视网膜旁黄斑容积均显著低于对照组（p=0.043，p=0.042，p=0.027，p=0.024，分别）。此外，BMI 与 SCP 和 DCP 的全层、旁黄斑和中心凹下血管密度以及所有血管和小血管的视盘周围血管密度值呈显著负相关（p=0.017，r=-0.327；p=0.043，r=-0.280；p=0.033，r=-0.293；p=0.034，r=-0.291；p=0.017，r=-0.327；p=0.023，r=-0.311；p=0.031，r=-0.296；p=0.047，r=-0.274，分别）。
我们认为肥胖患者视网膜血管密度和视网膜厚度的降低是肥胖引起的氧化应激、炎症细胞因子增加和微血管损伤的结果。
