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Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis: A Randomized Clinical Trial.预防性抗生素对严重酒精性肝炎患者死亡率的影响:一项随机临床试验。
JAMA. 2023 May 9;329(18):1558-1566. doi: 10.1001/jama.2023.4902.
2
Sex-specific association between alcohol consumption and liver cirrhosis: An updated systematic review and meta-analysis.饮酒与肝硬化之间的性别特异性关联:一项最新的系统评价与荟萃分析。
Front Gastroenterol (Lausanne). 2022;1. doi: 10.3389/fgstr.2022.1005729. Epub 2022 Oct 13.
3
Extra-hepatic morbidity and mortality in alcohol-related liver disease: Systematic review and meta-analysis.酒精性肝病的肝外发病率和死亡率:系统评价与荟萃分析
Liver Int. 2023 Apr;43(4):763-772. doi: 10.1111/liv.15526. Epub 2023 Feb 5.
4
Meta-analysis: Enhanced liver fibrosis test to identify hepatic fibrosis in chronic liver diseases.荟萃分析:增强型肝纤维化检测用于诊断慢性肝病中的肝纤维化。
Aliment Pharmacol Ther. 2023 Apr;57(7):750-762. doi: 10.1111/apt.17385. Epub 2023 Jan 17.
5
Deaths from alcohol-related liver disease in the UK: an escalating tragedy.英国酒精性肝病导致的死亡:一场不断升级的悲剧。
Lancet. 2023 Feb 11;401(10375):418-420. doi: 10.1016/S0140-6736(22)02583-1. Epub 2022 Dec 19.
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Alcohol Abstinence Improves Prognosis Across All Stages of Portal Hypertension in Alcohol-Related Cirrhosis.酒精戒断可改善酒精性肝硬化所有阶段门静脉高压的预后。
Clin Gastroenterol Hepatol. 2023 Aug;21(9):2308-2317.e7. doi: 10.1016/j.cgh.2022.11.033. Epub 2022 Dec 5.
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Simultaneous Management of Alcohol Use Disorder and Liver Disease: A Systematic Review and Meta-analysis.酒精使用障碍与肝病的同步管理:一项系统评价与荟萃分析。
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酒精性肝病管理的质量标准:英国肝脏研究协会和英国胃肠病学会酒精性肝病特别兴趣小组的共识建议

Quality standards for the management of alcohol-related liver disease: consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology ARLD special interest group.

作者信息

Parker Richard, Allison Michael, Anderson Seonaid, Aspinall Richard, Bardell Sara, Bains Vikram, Buchanan Ryan, Corless Lynsey, Davidson Ian, Dundas Pauline, Fernandez Jeff, Forrest Ewan, Forster Erica, Freshwater Dennis, Gailer Ruth, Goldin Robert, Hebditch Vanessa, Hood Steve, Jones Arron, Lavers Victoria, Lindsay Deborah, Maurice James, McDonagh Joanne, Morgan Sarah, Nurun Tania, Oldroyd Christopher, Oxley Elizabeth, Pannifex Sally, Parsons Graham, Phillips Thomas, Rainford Nicole, Rajoriya Neil, Richardson Paul, Ryan J, Sayer Joanne, Smith Mandy, Srivastava Ankur, Stennett Emma, Towey Jennifer, Vaziri Roya, Webzell Ian, Wellstead Andrew, Dhanda Ashwin, Masson Steven

机构信息

Leeds Liver Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK

Leeds Institute of Medical Research at St James's University Hospital, University of Leeds, Leeds, UK.

出版信息

BMJ Open Gastroenterol. 2023 Oct;10(1). doi: 10.1136/bmjgast-2023-001221.

DOI:10.1136/bmjgast-2023-001221
PMID:37797967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10551993/
Abstract

OBJECTIVE

Alcohol-related liver disease (ALD) is the most common cause of liver-related ill health and liver-related deaths in the UK, and deaths from ALD have doubled in the last decade. The management of ALD requires treatment of both liver disease and alcohol use; this necessitates effective and constructive multidisciplinary working. To support this, we have developed quality standard recommendations for the management of ALD, based on evidence and consensus expert opinion, with the aim of improving patient care.

DESIGN

A multidisciplinary group of experts from the British Association for the Study of the Liver and British Society of Gastroenterology ALD Special Interest Group developed the quality standards, with input from the British Liver Trust and patient representatives.

RESULTS

The standards cover three broad themes: the recognition and diagnosis of people with ALD in primary care and the liver outpatient clinic; the management of acutely decompensated ALD including acute alcohol-related hepatitis and the posthospital care of people with advanced liver disease due to ALD. Draft quality standards were initially developed by smaller working groups and then an anonymous modified Delphi voting process was conducted by the entire group to assess the level of agreement with each statement. Statements were included when agreement was 85% or greater. Twenty-four quality standards were produced from this process which support best practice. From the final list of statements, a smaller number of auditable key performance indicators were selected to allow services to benchmark their practice and an audit tool provided.

CONCLUSION

It is hoped that services will review their practice against these recommendations and key performance indicators and institute service development where needed to improve the care of patients with ALD.

摘要

目的

酒精性肝病(ALD)是英国肝脏相关健康问题和肝脏相关死亡的最常见原因,且在过去十年中,ALD导致的死亡人数翻了一番。ALD的管理需要同时治疗肝脏疾病和酒精使用问题;这就需要有效且具建设性的多学科协作。为支持这一点,我们基于证据和专家共识意见,制定了ALD管理的质量标准建议,旨在改善患者护理。

设计

来自英国肝脏研究协会和英国胃肠病学会ALD特别兴趣小组的多学科专家小组制定了这些质量标准,并得到了英国肝脏信托基金和患者代表的意见。

结果

这些标准涵盖三个广泛主题:在初级保健和肝脏门诊对ALD患者的识别与诊断;急性失代偿性ALD的管理,包括急性酒精性肝炎以及ALD所致晚期肝病患者的出院后护理。质量标准草案最初由较小的工作组制定,然后整个小组进行了匿名的德尔菲投票修改流程,以评估对每条陈述的认同程度。当认同度达到85%或更高时,相关陈述被纳入。通过这一过程产生了24条支持最佳实践的质量标准。从最终陈述列表中,选取了数量较少的可审计关键绩效指标,以便各医疗机构以此为基准评估自身实践,并提供了一种审计工具。

结论

希望各医疗机构对照这些建议和关键绩效指标审查自身实践,并在必要时开展服务改进,以改善ALD患者的护理。