肢端肥大症和生长激素缺乏症成人骨健康参数的差异：系统评价。
Differences between bone health parameters in adults with acromegaly and growth hormone deficiency: A systematic review.
机构信息
Vagelos College of Physicians and Surgeons, Columbia University, New York.
出版信息
Best Pract Res Clin Endocrinol Metab. 2023 Dec;37(6):101824. doi: 10.1016/j.beem.2023.101824. Epub 2023 Sep 28.
Preserving bone health is an important goal of care of patients with acromegaly and growth hormone deficiency (GHD). Both disorders are associated with compromised bone health and an increased risk of fracture. However, parameters of bone health that are routinely used to predict fractures in other populations, such as aBMD measured by DXA, are unreliable for this in acromegaly and GHD. Additional methodologies need to be employed to assess bone health in these patients. This review summarizes available data on the effects of acromegaly and GHD on parameters of bone health such as aBMD, volumetric bone mineral density (vBMD) and microarchitecture assessed by HRpQCT and other techniques, trabecular bone score (TBS) and fracture assessment. More research is needed to identify reliable predictors of fracture risk and to determine how best to screen for and treat those patients at risk so that bone health is optimized in these patients.
维护骨骼健康是治疗肢端肥大症和生长激素缺乏症（GHD）患者的重要目标。这两种疾病都与骨骼健康受损和骨折风险增加有关。然而，在其他人群中用于预测骨折的常规骨骼健康参数，如 DXA 测量的 aBMD，在肢端肥大症和 GHD 中并不可靠。需要采用其他方法来评估这些患者的骨骼健康。这篇综述总结了肢端肥大症和 GHD 对骨骼健康参数的影响，如 aBMD、通过 HRpQCT 和其他技术评估的体积骨密度（vBMD）和微结构、骨小梁评分（TBS）和骨折评估。需要更多的研究来确定骨折风险的可靠预测因子，并确定如何最好地筛查和治疗有风险的患者，从而优化这些患者的骨骼健康。
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