辅助生殖技术中肌醇从实验台到病床边的应用
Myo-inositol in assisted reproductive technology from bench to bedside.
作者信息
Etrusco Andrea, Laganà Antonio Simone, Chiantera Vito, Buzzaccarini Giovanni, Unfer Vittorio
机构信息
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy; Unit of Obstetrics and Gynecology, 'Paolo Giaccone' Hospital, Palermo, Italy.
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy; Unit of Obstetrics and Gynecology, 'Paolo Giaccone' Hospital, Palermo, Italy; The Experts Group on Inositol in Basic and Clinical Research (EGOI).
出版信息
Trends Endocrinol Metab. 2024 Jan;35(1):74-83. doi: 10.1016/j.tem.2023.09.005. Epub 2023 Oct 3.
Inositols are insulin-sensitizing compounds of promising efficacy in the management of polycystic ovary syndrome (PCOS). On the one hand, myo-inositol (myo-ins) plays a regulatory role in male and female reproductive function, influencing the development of oocytes, spermatozoa, and embryos. On the other hand, high concentrations of D-chiro-inositol (D-chiro-ins) in the ovary may adversely affect oocyte quality. This review analyses the available literature, which encourages the clinical use of myo-ins in assisted reproductive technologies (ARTs) due to its beneficial effects on female and male reproduction.
肌醇是一类具有胰岛素增敏作用的化合物，在多囊卵巢综合征（PCOS）的管理中显示出有前景的疗效。一方面，肌醇（myo-ins）在男性和女性生殖功能中发挥调节作用，影响卵母细胞、精子和胚胎的发育。另一方面，卵巢中高浓度的D-手性肌醇（D-chiro-ins）可能对卵母细胞质量产生不利影响。本综述分析了现有文献，因其对女性和男性生殖的有益作用，鼓励在辅助生殖技术（ARTs）中临床使用肌醇。
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