美金刚可抑制人胚肾293细胞中的内源性电流。 - Suppr

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超能文献

Endogenous currents in HEK 293 cells are inhibited by memantine.

作者信息

Harrison Neil L, Abbott Geoffrey W, McClenaghan Conor, Nichols Colin G, Cabrera-Garcia David

机构信息

Department of Anesthesiology, Columbia University, New York, NY, USA.

Departments of Anesthesiology and Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, USA.

出版信息

Nat Chem Biol. 2023 Nov;19(11):1303-1305. doi: 10.1038/s41589-023-01423-1. Epub 2023 Oct 5.

DOI:10.1038/s41589-023-01423-1

PMID:37798356

Abstract

摘要

相似文献

Endogenous currents in HEK 293 cells are inhibited by memantine.美金刚可抑制人胚肾293细胞中的内源性电流。

Nat Chem Biol. 2023 Nov;19(11):1303-1305. doi: 10.1038/s41589-023-01423-1. Epub 2023 Oct 5.

The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner.N-甲基-D-天冬氨酸受体通道阻滞剂美金刚、MRZ 2/579及其他氨基烷基环己烷以非竞争性方式拮抗培养的HEK-293和N1E-115细胞系统中的5-HT(3)受体电流。

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Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells.美金刚对在HEK 293细胞中表达的重组大鼠N-甲基-D-天冬氨酸受体的作用。

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Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation.N-甲基-D-天冬氨酸开放通道阻滞剂美金刚的神经保护浓度在缺血后给药时有效且不会导致细胞质空泡化，并且不会阻断迷宫学习或长时程增强。

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Indistinguishable synaptic pharmacodynamics of the N-methyl-D-aspartate receptor channel blockers memantine and ketamine.NMDA 受体通道阻滞剂美金刚和氯胺酮的突触药理学作用难以区分。

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Contribution of MATE1 to Renal Secretion of the NMDA Receptor Antagonist Memantine.MATE1 对 NMDA 受体拮抗剂美金刚肾脏分泌的贡献。

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Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons.在大鼠海马神经元中，美金刚对α7*烟碱型乙酰胆碱受体的阻断作用比N-甲基-D-天冬氨酸受体更强。

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Inhibition of human alpha 7 nicotinic acetylcholine receptors by open channel blockers of N-methyl-D-aspartate receptors.N-甲基-D-天冬氨酸受体开放通道阻滞剂对人α7烟碱型乙酰胆碱受体的抑制作用。

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Potency, voltage-dependency, agonist concentration-dependency, blocking kinetics and partial untrapping of the uncompetitive N-methyl-D-aspartate (NMDA) channel blocker memantine at human NMDA (GluN1/GluN2A) receptors.非竞争性N-甲基-D-天冬氨酸（NMDA）通道阻滞剂美金刚在人NMDA（GluN1/GluN2A）受体上的效能、电压依赖性、激动剂浓度依赖性、阻断动力学及部分解离

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Memantine inhibits [3H]MK-801 binding to human hippocampal NMDA receptors.美金刚抑制[3H]MK-801与人海马N-甲基-D-天冬氨酸受体的结合。

Neuroreport. 1994 Jun 2;5(10):1237-40. doi: 10.1097/00001756-199406020-00020.

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The envelope protein of SARS-CoV-2 increases intra-Golgi pH and forms a cation channel that is regulated by pH.SARS-CoV-2 的包膜蛋白会增加高尔基体腔内的 pH 值，并形成一个受 pH 值调节的阳离子通道。

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Front Immunol. 2020 Oct 9;11:573339. doi: 10.3389/fimmu.2020.573339. eCollection 2020.

Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of K1.3 potassium channels, AKT and ERK1/2 signaling.美金刚增强阿糖胞苷诱导的急性白血病细胞死亡，与抑制 K1.3 钾通道、AKT 和 ERK1/2 信号有关。

Cell Commun Signal. 2019 Jan 16;17(1):5. doi: 10.1186/s12964-018-0317-z.

The expression of endogenous voltage-gated potassium channels in HEK293 cells is affected by culture conditions.人胚肾293细胞中内源性电压门控钾通道的表达受培养条件影响。

Physiol Rep. 2018 Apr;6(8):e13663. doi: 10.14814/phy2.13663.

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