改良那不勒斯预后评分用于评估梗阻性结直肠癌患者的预后。
Modified Naples prognostic score for evaluating the prognosis of patients with obstructive colorectal cancer.
机构信息
Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China.
Department of Gastrointestinal Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China.
出版信息
BMC Cancer. 2023 Oct 5;23(1):941. doi: 10.1186/s12885-023-11435-8.
BACKGROUND
Inflammatory, immune, and nutritional status are key factors in obstructive colorectal cancer (OCRC). This study aims to investigate the value of modified Naples prognostic score (M-NPS) in evaluating OCRC prognosis.
METHODS
A total of 196 OCRC patients were retrospectively analyzed to construct M-NPS based on serum albumin (ALB), total cholesterol (CHOL), neutrophil:lymphocyte ratio (NLR), and lymphocyte:monocyte ratio (LMR), and then they were divided into three groups. The Kaplan-Meier (KM) method and Cox proportional hazard regression analysis were performed for overall survival (OS) and disease-free survival (DFS) of OCRC patients.
RESULTS
Patients with high M-NPS had worse OS and DFS (P = 0.0001, P = 0.0011). Multivariate COX analysis showed that M-NPS was an independent prognostic factor for OCRC patients. Patients in the M-NPS 2 group had significantly worse OS (hazard ratio [HR] = 4.930 (95% confidence interval [95% CI], 2.217-10.964), P < 0.001) and DFS (HR = 3.508 (95% CI, 1.691-7.277), P < 0.001) than those in the 0 group.
CONCLUSION
M-NPS was an independent prognostic factor for OCRC patients; it might provide a potential reference for immunonutritional intervention in patients with obstruction.
背景
炎症、免疫和营养状况是阻塞性结直肠癌（OCRC）的关键因素。本研究旨在探讨改良那不勒斯预后评分（M-NPS）在评估 OCRC 预后中的价值。
方法
回顾性分析了 196 例 OCRC 患者，基于血清白蛋白（ALB）、总胆固醇（CHOL）、中性粒细胞与淋巴细胞比值（NLR）和淋巴细胞与单核细胞比值（LMR）构建 M-NPS，并将其分为三组。采用 Kaplan-Meier（KM）法和 Cox 比例风险回归分析 OCRC 患者的总生存期（OS）和无病生存期（DFS）。
结果
M-NPS 高的患者 OS 和 DFS 较差（P=0.0001，P=0.0011）。多因素 COX 分析显示，M-NPS 是 OCRC 患者的独立预后因素。M-NPS 2 组患者的 OS（风险比[HR] = 4.930（95%置信区间[95%CI]，2.217-10.964），P<0.001）和 DFS（HR = 3.508（95% CI，1.691-7.277），P<0.001）明显差于 0 组。
结论
M-NPS 是 OCRC 患者的独立预后因素；它可能为梗阻患者的免疫营养干预提供潜在参考。
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